Reduced gluconeogenesis and lactate clearance in Huntington's disease

Knud Elnegaard Josefsen; Signe M B Nielsen; André Campos; Thomas Seifert; Lis Frydenreich Hasholt; Jørgen E Nielsen; Anne Nørremølle; Niels Henning Skotte; Niels H Secher; Bjørn Quistorff

doi:10.1016/j.nbd.2010.08.009

Reduced gluconeogenesis and lactate clearance in Huntington's disease

Knud Elnegaard Josefsen, Signe M B Nielsen, André Campos, Thomas Seifert, Lis Frydenreich Hasholt, Jørgen E Nielsen, Anne Nørremølle, Niels Henning Skotte, Niels H Secher, Bjørn Quistorff

34 Citationer (Scopus)

Abstrakt

We studied systemic and brain glucose and lactate metabolism in Huntington's disease (HD) patients in response to ergometer cycling. Following termination of exercise, blood glucose increased abruptly in control subjects, but no peak was seen in any of the HD patients (2.0 ± 0.5 vs. 0.0 ± 0.2mM, P <2 × 10(-6)). No difference was seen in brain metabolism parameters. Reduced hepatic glucose output in the HD mouse model R6/2 following a lactate challenge, combined with reduced phosphoenolpyruvate carboxykinase and increased pyruvate kinase activity in the mouse liver suggest a reduced capacity for gluconeogenesis in HD, possibly contributing to the clinical symptoms of HD. We propose that blood glucose concentration in the recovery from exercise can be applied as a liver function test in HD patients.

Originalsprog	Engelsk
Tidsskrift	Neurobiology of Disease
Vol/bind	40
Udgave nummer	3
Sider (fra-til)	656-62
Antal sider	7
ISSN	0969-9961
DOI	https://doi.org/10.1016/j.nbd.2010.08.009
Status	Udgivet - 1 dec. 2010

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10.1016/j.nbd.2010.08.009

Citationsformater

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title = "Reduced gluconeogenesis and lactate clearance in Huntington's disease",

abstract = "We studied systemic and brain glucose and lactate metabolism in Huntington's disease (HD) patients in response to ergometer cycling. Following termination of exercise, blood glucose increased abruptly in control subjects, but no peak was seen in any of the HD patients (2.0 ± 0.5 vs. 0.0 ± 0.2mM, P <2 × 10(-6)). No difference was seen in brain metabolism parameters. Reduced hepatic glucose output in the HD mouse model R6/2 following a lactate challenge, combined with reduced phosphoenolpyruvate carboxykinase and increased pyruvate kinase activity in the mouse liver suggest a reduced capacity for gluconeogenesis in HD, possibly contributing to the clinical symptoms of HD. We propose that blood glucose concentration in the recovery from exercise can be applied as a liver function test in HD patients.",

author = "Josefsen, {Knud Elnegaard} and Nielsen, {Signe M B} and Andr{\'e} Campos and Thomas Seifert and Hasholt, {Lis Frydenreich} and Nielsen, {J{\o}rgen E} and Anne N{\o}rrem{\o}lle and Skotte, {Niels Henning} and Secher, {Niels H} and Bj{\o}rn Quistorff",

year = "2010",

month = dec,

day = "1",

doi = "10.1016/j.nbd.2010.08.009",

language = "English",

volume = "40",

pages = "656--62",

journal = "Neurobiology of Disease",

issn = "0969-9961",

publisher = "Academic Press",

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TY - JOUR

T1 - Reduced gluconeogenesis and lactate clearance in Huntington's disease

AU - Josefsen, Knud Elnegaard

AU - Nielsen, Signe M B

AU - Campos, André

AU - Seifert, Thomas

AU - Hasholt, Lis Frydenreich

AU - Nielsen, Jørgen E

AU - Nørremølle, Anne

AU - Skotte, Niels Henning

AU - Secher, Niels H

AU - Quistorff, Bjørn

PY - 2010/12/1

Y1 - 2010/12/1

N2 - We studied systemic and brain glucose and lactate metabolism in Huntington's disease (HD) patients in response to ergometer cycling. Following termination of exercise, blood glucose increased abruptly in control subjects, but no peak was seen in any of the HD patients (2.0 ± 0.5 vs. 0.0 ± 0.2mM, P <2 × 10(-6)). No difference was seen in brain metabolism parameters. Reduced hepatic glucose output in the HD mouse model R6/2 following a lactate challenge, combined with reduced phosphoenolpyruvate carboxykinase and increased pyruvate kinase activity in the mouse liver suggest a reduced capacity for gluconeogenesis in HD, possibly contributing to the clinical symptoms of HD. We propose that blood glucose concentration in the recovery from exercise can be applied as a liver function test in HD patients.

AB - We studied systemic and brain glucose and lactate metabolism in Huntington's disease (HD) patients in response to ergometer cycling. Following termination of exercise, blood glucose increased abruptly in control subjects, but no peak was seen in any of the HD patients (2.0 ± 0.5 vs. 0.0 ± 0.2mM, P <2 × 10(-6)). No difference was seen in brain metabolism parameters. Reduced hepatic glucose output in the HD mouse model R6/2 following a lactate challenge, combined with reduced phosphoenolpyruvate carboxykinase and increased pyruvate kinase activity in the mouse liver suggest a reduced capacity for gluconeogenesis in HD, possibly contributing to the clinical symptoms of HD. We propose that blood glucose concentration in the recovery from exercise can be applied as a liver function test in HD patients.

U2 - 10.1016/j.nbd.2010.08.009

DO - 10.1016/j.nbd.2010.08.009

M3 - Journal article

C2 - 20727971

VL - 40

SP - 656

EP - 662

JO - Neurobiology of Disease

JF - Neurobiology of Disease

SN - 0969-9961

IS - 3

ER -

Reduced gluconeogenesis and lactate clearance in Huntington's disease

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