Reduced frequency of blood group Lewis a-b- in female Type 1 diabetes patients

A V Kharagjitsingh; K Prinsen; H H P J Lemkes; R R P de Vries; B O Roep; K Buschard

doi:10.1111/j.1464-5491.2007.02340.x

Reduced frequency of blood group Lewis a-b- in female Type 1 diabetes patients

A V Kharagjitsingh, K Prinsen, H H P J Lemkes, R R P de Vries, B O Roep, K Buschard

Afdeling for Patologi

2 Citationer (Scopus)

Abstract

AIMS: To examine a disputed association between the Lewis(a(-)b(-)) phenotype and Type 1 diabetes (T1D).

METHODS: Lewis red blood cell phenotyping was performed for 97 T1D White patients and 100 control subjects using monoclonal antibodies. Two historical cohorts were also included as a control population.

RESULTS: T1D patients had a lower frequency (4.1%) of Lewis(a(-)b(-)) blood group compared with simultaneously tested healthy control subjects (10.0%) and the historical control group (11.1%, P = 0.02). Male T1D patients showed a Lewis(a(-)b(-)) frequency of 8.0%, which was similar to both matched healthy male donors (9.8%) and historical (9.5%) male control subjects. Unexpectedly, none of the female T1D patients displayed Lewis(a(-)b(-)) phenotype, vs. 10.3% and 10.8% of female control subjects (P = 0.039 and 0.017).

CONCLUSIONS: The Lewis(a(-)b(-)) phenotype occurs less frequently in T1D compared with healthy control subjects with a strong female gender bias.

Originalsprog	Engelsk
Tidsskrift	Diabetic medicine : a journal of the British Diabetic Association
Vol/bind	25
Udgave nummer	2
Sider (fra-til)	236-8
Antal sider	3
ISSN	0742-3071
DOI	https://doi.org/10.1111/j.1464-5491.2007.02340.x
Status	Udgivet - feb. 2008

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10.1111/j.1464-5491.2007.02340.x

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title = "Reduced frequency of blood group Lewis a-b- in female Type 1 diabetes patients",

abstract = "AIMS: To examine a disputed association between the Lewis(a(-)b(-)) phenotype and Type 1 diabetes (T1D).METHODS: Lewis red blood cell phenotyping was performed for 97 T1D White patients and 100 control subjects using monoclonal antibodies. Two historical cohorts were also included as a control population.RESULTS: T1D patients had a lower frequency (4.1%) of Lewis(a(-)b(-)) blood group compared with simultaneously tested healthy control subjects (10.0%) and the historical control group (11.1%, P = 0.02). Male T1D patients showed a Lewis(a(-)b(-)) frequency of 8.0%, which was similar to both matched healthy male donors (9.8%) and historical (9.5%) male control subjects. Unexpectedly, none of the female T1D patients displayed Lewis(a(-)b(-)) phenotype, vs. 10.3% and 10.8% of female control subjects (P = 0.039 and 0.017).CONCLUSIONS: The Lewis(a(-)b(-)) phenotype occurs less frequently in T1D compared with healthy control subjects with a strong female gender bias.",

keywords = "Adolescent, Adult, Aged, Antibodies, Bacterial/analysis, Diabetes Mellitus, Type 1/blood, Female, Helicobacter Infections/blood, Helicobacter pylori/immunology, Humans, Immunophenotyping, Lewis Blood Group Antigens/blood, Male, Middle Aged, Phenotype, Polymorphism, Genetic, Sex Factors",

author = "Kharagjitsingh, {A V} and K Prinsen and Lemkes, {H H P J} and {de Vries}, {R R P} and Roep, {B O} and K Buschard",

year = "2008",

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doi = "10.1111/j.1464-5491.2007.02340.x",

language = "English",

volume = "25",

pages = "236--8",

journal = "Diabetic medicine : a journal of the British Diabetic Association",

issn = "0742-3071",

publisher = "Wiley-Blackwell Publishing Ltd",

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TY - JOUR

T1 - Reduced frequency of blood group Lewis a-b- in female Type 1 diabetes patients

AU - Kharagjitsingh, A V

AU - Prinsen, K

AU - Lemkes, H H P J

AU - de Vries, R R P

AU - Roep, B O

AU - Buschard, K

PY - 2008/2

Y1 - 2008/2

N2 - AIMS: To examine a disputed association between the Lewis(a(-)b(-)) phenotype and Type 1 diabetes (T1D).METHODS: Lewis red blood cell phenotyping was performed for 97 T1D White patients and 100 control subjects using monoclonal antibodies. Two historical cohorts were also included as a control population.RESULTS: T1D patients had a lower frequency (4.1%) of Lewis(a(-)b(-)) blood group compared with simultaneously tested healthy control subjects (10.0%) and the historical control group (11.1%, P = 0.02). Male T1D patients showed a Lewis(a(-)b(-)) frequency of 8.0%, which was similar to both matched healthy male donors (9.8%) and historical (9.5%) male control subjects. Unexpectedly, none of the female T1D patients displayed Lewis(a(-)b(-)) phenotype, vs. 10.3% and 10.8% of female control subjects (P = 0.039 and 0.017).CONCLUSIONS: The Lewis(a(-)b(-)) phenotype occurs less frequently in T1D compared with healthy control subjects with a strong female gender bias.

AB - AIMS: To examine a disputed association between the Lewis(a(-)b(-)) phenotype and Type 1 diabetes (T1D).METHODS: Lewis red blood cell phenotyping was performed for 97 T1D White patients and 100 control subjects using monoclonal antibodies. Two historical cohorts were also included as a control population.RESULTS: T1D patients had a lower frequency (4.1%) of Lewis(a(-)b(-)) blood group compared with simultaneously tested healthy control subjects (10.0%) and the historical control group (11.1%, P = 0.02). Male T1D patients showed a Lewis(a(-)b(-)) frequency of 8.0%, which was similar to both matched healthy male donors (9.8%) and historical (9.5%) male control subjects. Unexpectedly, none of the female T1D patients displayed Lewis(a(-)b(-)) phenotype, vs. 10.3% and 10.8% of female control subjects (P = 0.039 and 0.017).CONCLUSIONS: The Lewis(a(-)b(-)) phenotype occurs less frequently in T1D compared with healthy control subjects with a strong female gender bias.

KW - Adolescent

KW - Adult

KW - Aged

KW - Antibodies, Bacterial/analysis

KW - Diabetes Mellitus, Type 1/blood

KW - Female

KW - Helicobacter Infections/blood

KW - Helicobacter pylori/immunology

KW - Humans

KW - Immunophenotyping

KW - Lewis Blood Group Antigens/blood

KW - Male

KW - Middle Aged

KW - Phenotype

KW - Polymorphism, Genetic

KW - Sex Factors

U2 - 10.1111/j.1464-5491.2007.02340.x

DO - 10.1111/j.1464-5491.2007.02340.x

M3 - Journal article

C2 - 18215173

SN - 0742-3071

VL - 25

SP - 236

EP - 238

JO - Diabetic medicine : a journal of the British Diabetic Association

JF - Diabetic medicine : a journal of the British Diabetic Association

IS - 2

ER -

Reduced frequency of blood group Lewis a-b- in female Type 1 diabetes patients

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