Abstract
Introduction: Chronic infection with herpes viruses is a potential contributing factor to the development of dementia. The introduction of nationwide shingles (varicella zoster) vaccination in Wales might therefore be associated with reduced incident dementia.
Methods: We analyzed the association of shingles vaccination with incident dementia in Wales between 2013 and 2020 using retrospectively collected national health data.
Results: Vaccinated individuals were at reduced risk of dementia (adjusted hazard ratio: 0.72; 95% confidence interval: 0.69 to 0.75). The association was not modified by a reduction in shingles diagnosis and was stronger for vascular dementia than for Alzheimer's disease. Vaccination was also associated with a reduction in several other diseases and all-cause mortality.
Discussion: Our study shows a clear association of shingles vaccination with reduced dementia, consistent with other observational cohort studies. The association may reflect selection bias with people choosing to be vaccinated having a higher healthy life expectancy.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | e12293 |
| Tidsskrift | Alzheimer's & Dementia: Translational Research & Clinical Interventions |
| Vol/bind | 8 |
| Udgave nummer | 1 |
| Sider (fra-til) | 1-7 |
| Antal sider | 7 |
| ISSN | 2352-8737 |
| DOI | |
| Status | Udgivet - 2022 |