Reduced cellular immune reactivity in healthy individuals during the malaria transmission season

T G Theander; L Hviid; Y A Abu-Zeid; N H Abdulhadi; B O Saeed; P H Jakobsen; C M Reimert; S Jepsen; R A Bayoumi; J B Jensen

doi:10.1016/0165-2478(90)90121-6

Reduced cellular immune reactivity in healthy individuals during the malaria transmission season

T G Theander, L Hviid, Y A Abu-Zeid, N H Abdulhadi, B O Saeed, P H Jakobsen, C M Reimert, S Jepsen, R A Bayoumi, J B Jensen

31 Citationer (Scopus)

Abstract

Antigen-induced cellular immune responses are suppressed during acute malaria. The present study engages the possibility that malaria-induced alterations in cellular immune reactivity extend beyond the clinical disease. Thus, lymphoproliferative responses of healthy individuals were diminished during the malaria transmission period in individuals living in an area of highly seasonal, unstable malaria transmission. This finding may have important implications for the design of studies of stimulatory properties of antigens using lymphocytes of endemic origin.

Originalsprog	Engelsk
Tidsskrift	Immunology Letters
Vol/bind	25
Udgave nummer	1-3
Sider (fra-til)	237-42
Antal sider	6
ISSN	0165-2478
DOI	https://doi.org/10.1016/0165-2478(90)90121-6
Status	Udgivet - aug. 1990
Udgivet eksternt	Ja

Adgang til dokumentet

10.1016/0165-2478(90)90121-6

Citationsformater

@article{a939f46e012c4fd08cd80c732556628b,

title = "Reduced cellular immune reactivity in healthy individuals during the malaria transmission season",

abstract = "Antigen-induced cellular immune responses are suppressed during acute malaria. The present study engages the possibility that malaria-induced alterations in cellular immune reactivity extend beyond the clinical disease. Thus, lymphoproliferative responses of healthy individuals were diminished during the malaria transmission period in individuals living in an area of highly seasonal, unstable malaria transmission. This finding may have important implications for the design of studies of stimulatory properties of antigens using lymphocytes of endemic origin.",

keywords = "Adolescent, Adult, Animals, Antibodies, Protozoan/analysis, Antigens, Protozoan/immunology, Antigens, Surface/immunology, Child, Child, Preschool, Female, Humans, Lymphocyte Activation/drug effects, Malaria/immunology, Male, Middle Aged, Phytohemagglutinins/pharmacology, Plasmodium/immunology, Protozoan Proteins/immunology, Seasons, Sudan, Tuberculin/immunology",

author = "Theander, {T G} and L Hviid and Abu-Zeid, {Y A} and Abdulhadi, {N H} and Saeed, {B O} and Jakobsen, {P H} and Reimert, {C M} and S Jepsen and Bayoumi, {R A} and Jensen, {J B}",

year = "1990",

month = aug,

doi = "10.1016/0165-2478(90)90121-6",

language = "English",

volume = "25",

pages = "237--42",

journal = "Immunology Letters",

issn = "0165-2478",

publisher = "Elsevier BV",

number = "1-3",

}

TY - JOUR

T1 - Reduced cellular immune reactivity in healthy individuals during the malaria transmission season

AU - Theander, T G

AU - Hviid, L

AU - Abu-Zeid, Y A

AU - Abdulhadi, N H

AU - Saeed, B O

AU - Jakobsen, P H

AU - Reimert, C M

AU - Jepsen, S

AU - Bayoumi, R A

AU - Jensen, J B

PY - 1990/8

Y1 - 1990/8

N2 - Antigen-induced cellular immune responses are suppressed during acute malaria. The present study engages the possibility that malaria-induced alterations in cellular immune reactivity extend beyond the clinical disease. Thus, lymphoproliferative responses of healthy individuals were diminished during the malaria transmission period in individuals living in an area of highly seasonal, unstable malaria transmission. This finding may have important implications for the design of studies of stimulatory properties of antigens using lymphocytes of endemic origin.

AB - Antigen-induced cellular immune responses are suppressed during acute malaria. The present study engages the possibility that malaria-induced alterations in cellular immune reactivity extend beyond the clinical disease. Thus, lymphoproliferative responses of healthy individuals were diminished during the malaria transmission period in individuals living in an area of highly seasonal, unstable malaria transmission. This finding may have important implications for the design of studies of stimulatory properties of antigens using lymphocytes of endemic origin.

KW - Adolescent

KW - Adult

KW - Animals

KW - Antibodies, Protozoan/analysis

KW - Antigens, Protozoan/immunology

KW - Antigens, Surface/immunology

KW - Child

KW - Child, Preschool

KW - Female

KW - Humans

KW - Lymphocyte Activation/drug effects

KW - Malaria/immunology

KW - Male

KW - Middle Aged

KW - Phytohemagglutinins/pharmacology

KW - Plasmodium/immunology

KW - Protozoan Proteins/immunology

KW - Seasons

KW - Sudan

KW - Tuberculin/immunology

U2 - 10.1016/0165-2478(90)90121-6

DO - 10.1016/0165-2478(90)90121-6

M3 - Journal article

C2 - 2283153

SN - 0165-2478

VL - 25

SP - 237

EP - 242

JO - Immunology Letters

JF - Immunology Letters

IS - 1-3

ER -

Reduced cellular immune reactivity in healthy individuals during the malaria transmission season

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater