Recombinant HCV Variants With NS5A From Genotypes 1-7 Have Different Sensitivities to an NS5A Inhibitor but Not Interferon-α

Troels Scheel; Judith Gottwein; Lotte Mikkelsen; Tanja B Jensen; Jens Bukh

doi:10.1053/j.gastro.2010.11.036

Recombinant HCV Variants With NS5A From Genotypes 1-7 Have Different Sensitivities to an NS5A Inhibitor but Not Interferon-α

Troels Scheel, Judith Gottwein, Lotte Mikkelsen, Tanja B Jensen, Jens Bukh

130 Citationer (Scopus)

Abstract

Udgivelsesdato: 2011-Mar

Originalsprog	Engelsk
Tidsskrift	Gastroenterology
Vol/bind	140
Udgave nummer	3
Sider (fra-til)	1032-1042.e6
DOI	https://doi.org/10.1053/j.gastro.2010.11.036
Status	Udgivet - mar. 2011

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10.1053/j.gastro.2010.11.036

Citationsformater

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title = "Recombinant HCV Variants With NS5A From Genotypes 1-7 Have Different Sensitivities to an NS5A Inhibitor but Not Interferon-α",

abstract = "Heterogeneity in the hepatitis C virus (HCV) protein NS5A influences its sensitivity to interferon-based therapy. Furthermore, NS5A is an important target for development of HCV-specific inhibitors. We aimed to develop recombinant infectious cell culture systems that express NS5A from isolates of the 7 major HCV genotypes, and determining their sensitivity to a specific NS5A inhibitor and to interferon-α.",

author = "Troels Scheel and Judith Gottwein and Lotte Mikkelsen and Jensen, {Tanja B} and Jens Bukh",

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AU - Mikkelsen, Lotte

AU - Jensen, Tanja B

AU - Bukh, Jens

PY - 2011/3

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AB - Heterogeneity in the hepatitis C virus (HCV) protein NS5A influences its sensitivity to interferon-based therapy. Furthermore, NS5A is an important target for development of HCV-specific inhibitors. We aimed to develop recombinant infectious cell culture systems that express NS5A from isolates of the 7 major HCV genotypes, and determining their sensitivity to a specific NS5A inhibitor and to interferon-α.

U2 - 10.1053/j.gastro.2010.11.036

DO - 10.1053/j.gastro.2010.11.036

M3 - Journal article

C2 - 21111742

SN - 1528-0012

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SP - 1032-1042.e6

JO - Gastroenterology

JF - Gastroenterology

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Recombinant HCV Variants With NS5A From Genotypes 1-7 Have Different Sensitivities to an NS5A Inhibitor but Not Interferon-α

Abstract

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