Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Recent increase in incidence of invasive serogroup W meningococcal disease. A retrospective observational study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Oral and anal carriage of Neisseria meningitidis among sexually active HIV-infected men who have sex with men in Denmark 2014-15

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Silent Hypoxia in Patients with SARS CoV-2 Infection before Hospital Discharge

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Epidemiology of hepatitis E virus infection in a cohort of 4023 immunocompromised patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVES: Neisseria meningitidis serogroup W incidence has increased. Mortality associated with serogroup W has been higher than for other serogroups. Here we report epidemiological characteristics and risks of poor outcomes associated with invasive meningococcal disease in Denmark since 1980.

METHODS: All cases of invasive meningococcal disease reported from 1980-2018 were analyzed. Incidence rates by age, sex, manifestation, and serogroup were calculated. Poisson regression was used to analyze the rise in serogroup W and multivariate logistic analysis was used to analyze risk factors for mortality.

RESULTS: A total of 5825 cases were analyzed. Risk of serogroup W infection increased after 2015 compared to all previous time periods. Similarly, younger (<20 years) and older age (≥60 years) was associated with an increased risk of serogroup W infection compared to being 20-39-year-old. Crude case fatality was 12.0%, 11.9%, 9.2%, and 7.9% for serogroups W, Y, C, and B, respectively. After adjustment for age, sex, and manifestation 30-day mortality was comparable for serogroups. Older age and manifestation with sepsis independently predicted risk of death.

CONCLUSIONS: Invasive meningococcal disease caused by serogroup W has increased but serogroup per se was not associated with an increased risk of 30-day mortality.

OriginalsprogEngelsk
TidsskriftInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ISSN1201-9712
DOI
StatusE-pub ahead of print - 5 jun. 2021

ID: 66134309