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Recall of symptoms and treatment of syphilis and yaws by healthy blood donors screening positive for syphilis in Kumasi, Ghana

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@article{6c7dacaea70f4b1191dde0e66cb03e92,
title = "Recall of symptoms and treatment of syphilis and yaws by healthy blood donors screening positive for syphilis in Kumasi, Ghana",
abstract = "OBJECTIVE: To describe the recalled medical history, clinical manifestations, and treatment of yaws and syphilis by syphilis seroreactive blood donors in Kumasi, Ghana.METHODS: Of the blood donors at Komfo Anokye Teaching Hospital, Kumasi, Ghana tested with the syphilis rapid diagnostic test (RDT) and later by rapid plasma reagin (RPR) test, 526 were seroreactive. Four hundred and seventy-one (89.5{\%}) of these subjects were confirmed with the Ortho-Vitros Syphilis TP test as the gold standard and were interviewed to determine past or present clinical manifestations of yaws and syphilis.RESULTS: Of the 471 respondent donors, 28 (5.9{\%}) gave a history of skin lesions and sores; four (14.3{\%}) of these subjects, who were all male and RPR-positive, recalled a diagnosis of syphilis. All four reported having had skin lesions/bumps with slow-healing sores, but only one of them had had these symptoms before the age of 15 years.CONCLUSIONS: A small proportion of confirmed seroreactive donors in this sample had any recall of symptoms or treatment for yaws or syphilis. These data suggest that clinical questioning adds little further information to the current screening algorithm. The relative contribution of yaws and syphilis to frequent positive tests in endemic areas remains speculative.",
keywords = "Journal Article",
author = "Francis Sarkodie and Ellis Owusu-Dabo and Oliver Hassall and Imelda Bates and Bygbjerg, {Ib C} and Henrik Ullum",
note = "Copyright {\circledC} 2016 The Author(s). Published by Elsevier Ltd.. All rights reserved.",
year = "2016",
month = "9",
doi = "10.1016/j.ijid.2016.08.006",
language = "English",
volume = "50",
pages = "72--4",
journal = "International Journal of Infectious Diseases",
issn = "1201-9712",
publisher = "Elsevier Ltd",

}

RIS

TY - JOUR

T1 - Recall of symptoms and treatment of syphilis and yaws by healthy blood donors screening positive for syphilis in Kumasi, Ghana

AU - Sarkodie, Francis

AU - Owusu-Dabo, Ellis

AU - Hassall, Oliver

AU - Bates, Imelda

AU - Bygbjerg, Ib C

AU - Ullum, Henrik

N1 - Copyright © 2016 The Author(s). Published by Elsevier Ltd.. All rights reserved.

PY - 2016/9

Y1 - 2016/9

N2 - OBJECTIVE: To describe the recalled medical history, clinical manifestations, and treatment of yaws and syphilis by syphilis seroreactive blood donors in Kumasi, Ghana.METHODS: Of the blood donors at Komfo Anokye Teaching Hospital, Kumasi, Ghana tested with the syphilis rapid diagnostic test (RDT) and later by rapid plasma reagin (RPR) test, 526 were seroreactive. Four hundred and seventy-one (89.5%) of these subjects were confirmed with the Ortho-Vitros Syphilis TP test as the gold standard and were interviewed to determine past or present clinical manifestations of yaws and syphilis.RESULTS: Of the 471 respondent donors, 28 (5.9%) gave a history of skin lesions and sores; four (14.3%) of these subjects, who were all male and RPR-positive, recalled a diagnosis of syphilis. All four reported having had skin lesions/bumps with slow-healing sores, but only one of them had had these symptoms before the age of 15 years.CONCLUSIONS: A small proportion of confirmed seroreactive donors in this sample had any recall of symptoms or treatment for yaws or syphilis. These data suggest that clinical questioning adds little further information to the current screening algorithm. The relative contribution of yaws and syphilis to frequent positive tests in endemic areas remains speculative.

AB - OBJECTIVE: To describe the recalled medical history, clinical manifestations, and treatment of yaws and syphilis by syphilis seroreactive blood donors in Kumasi, Ghana.METHODS: Of the blood donors at Komfo Anokye Teaching Hospital, Kumasi, Ghana tested with the syphilis rapid diagnostic test (RDT) and later by rapid plasma reagin (RPR) test, 526 were seroreactive. Four hundred and seventy-one (89.5%) of these subjects were confirmed with the Ortho-Vitros Syphilis TP test as the gold standard and were interviewed to determine past or present clinical manifestations of yaws and syphilis.RESULTS: Of the 471 respondent donors, 28 (5.9%) gave a history of skin lesions and sores; four (14.3%) of these subjects, who were all male and RPR-positive, recalled a diagnosis of syphilis. All four reported having had skin lesions/bumps with slow-healing sores, but only one of them had had these symptoms before the age of 15 years.CONCLUSIONS: A small proportion of confirmed seroreactive donors in this sample had any recall of symptoms or treatment for yaws or syphilis. These data suggest that clinical questioning adds little further information to the current screening algorithm. The relative contribution of yaws and syphilis to frequent positive tests in endemic areas remains speculative.

KW - Journal Article

U2 - 10.1016/j.ijid.2016.08.006

DO - 10.1016/j.ijid.2016.08.006

M3 - Journal article

VL - 50

SP - 72

EP - 74

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

SN - 1201-9712

ER -

ID: 49163140