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Real-World Use of Do-It-Yourself Artificial Pancreas Systems in Children and Adolescents With Type 1 Diabetes: Online Survey and Analysis of Self-Reported Clinical Outcomes

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@article{ce870485a58b4432a9e26343de1af7e5,
title = "Real-World Use of Do-It-Yourself Artificial Pancreas Systems in Children and Adolescents With Type 1 Diabetes: Online Survey and Analysis of Self-Reported Clinical Outcomes",
abstract = "Background: Patient-driven initiatives have made uptake of Do-it-Yourself Artificial Pancreas Systems (DIYAPS) increasingly popular among people with diabetes of all ages. Observational studies have shown improvements in glycemic control and quality of life among adults with diabetes. However, there is a lack of research examining outcomes of children and adolescents with DIYAPS in everyday life and their social context. Objective: This survey assesses the self-reported clinical outcomes of a pediatric population using DIYAPS in the real world. Methods: An online survey was distributed to caregivers to assess the hemoglobin A1c levels and time in range (TIR) before and after DIYAPS initiation and problems during DIYAPS use. Results: A total of 209 caregivers of children from 21 countries responded to the survey. Of the children, 47.4{\%} were female, with a median age of 10 years, and 99.4{\%} had type 1 diabetes, with a median duration of 4.3 years (SD 3.9). The median duration of DIYAPS use was 7.5 (SD 10.0) months. Clinical outcomes improved significantly, including the hemoglobin A1c levels (from 6.91{\%} [SD 0.88{\%}] to 6.27{\%} [SD 0.67]; P<.001) and TIR (from 64.2{\%} [SD 15.94] to 80.68{\%} [SD 9.26]; P<.001). Conclusions: Improved glycemic outcomes were found across all pediatric age groups, including adolescents and very young children. These findings are in line with clinical trial results from commercially developed closed-loop systems.",
keywords = "Artificial pancreas, Automated insulin delivery, Closed loop, Diabetes, Do it yourself, Mobile health, Open source, Pediatric diabetes, Type 1 diabetes",
author = "Katarina Braune and Shane O'Donnell and Bryan Cleal and Dana Lewis and Adrian Tappe and Ingrid Willaing and Bastian Hauck and Klemens Raile",
note = "{\circledC}Katarina Braune, Shane O'Donnell, Bryan Cleal, Dana Lewis, Adrian Tappe, Ingrid Willaing, Bastian Hauck, Klemens Raile. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 30.07.2019.",
year = "2019",
month = "7",
day = "30",
doi = "10.2196/14087",
language = "English",
volume = "7",
journal = "J M I R mHealth and uHealth",
issn = "2291-5222",
publisher = "J M I R Publications, Inc.",
number = "7",

}

RIS

TY - JOUR

T1 - Real-World Use of Do-It-Yourself Artificial Pancreas Systems in Children and Adolescents With Type 1 Diabetes

T2 - Online Survey and Analysis of Self-Reported Clinical Outcomes

AU - Braune, Katarina

AU - O'Donnell, Shane

AU - Cleal, Bryan

AU - Lewis, Dana

AU - Tappe, Adrian

AU - Willaing, Ingrid

AU - Hauck, Bastian

AU - Raile, Klemens

N1 - ©Katarina Braune, Shane O'Donnell, Bryan Cleal, Dana Lewis, Adrian Tappe, Ingrid Willaing, Bastian Hauck, Klemens Raile. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 30.07.2019.

PY - 2019/7/30

Y1 - 2019/7/30

N2 - Background: Patient-driven initiatives have made uptake of Do-it-Yourself Artificial Pancreas Systems (DIYAPS) increasingly popular among people with diabetes of all ages. Observational studies have shown improvements in glycemic control and quality of life among adults with diabetes. However, there is a lack of research examining outcomes of children and adolescents with DIYAPS in everyday life and their social context. Objective: This survey assesses the self-reported clinical outcomes of a pediatric population using DIYAPS in the real world. Methods: An online survey was distributed to caregivers to assess the hemoglobin A1c levels and time in range (TIR) before and after DIYAPS initiation and problems during DIYAPS use. Results: A total of 209 caregivers of children from 21 countries responded to the survey. Of the children, 47.4% were female, with a median age of 10 years, and 99.4% had type 1 diabetes, with a median duration of 4.3 years (SD 3.9). The median duration of DIYAPS use was 7.5 (SD 10.0) months. Clinical outcomes improved significantly, including the hemoglobin A1c levels (from 6.91% [SD 0.88%] to 6.27% [SD 0.67]; P<.001) and TIR (from 64.2% [SD 15.94] to 80.68% [SD 9.26]; P<.001). Conclusions: Improved glycemic outcomes were found across all pediatric age groups, including adolescents and very young children. These findings are in line with clinical trial results from commercially developed closed-loop systems.

AB - Background: Patient-driven initiatives have made uptake of Do-it-Yourself Artificial Pancreas Systems (DIYAPS) increasingly popular among people with diabetes of all ages. Observational studies have shown improvements in glycemic control and quality of life among adults with diabetes. However, there is a lack of research examining outcomes of children and adolescents with DIYAPS in everyday life and their social context. Objective: This survey assesses the self-reported clinical outcomes of a pediatric population using DIYAPS in the real world. Methods: An online survey was distributed to caregivers to assess the hemoglobin A1c levels and time in range (TIR) before and after DIYAPS initiation and problems during DIYAPS use. Results: A total of 209 caregivers of children from 21 countries responded to the survey. Of the children, 47.4% were female, with a median age of 10 years, and 99.4% had type 1 diabetes, with a median duration of 4.3 years (SD 3.9). The median duration of DIYAPS use was 7.5 (SD 10.0) months. Clinical outcomes improved significantly, including the hemoglobin A1c levels (from 6.91% [SD 0.88%] to 6.27% [SD 0.67]; P<.001) and TIR (from 64.2% [SD 15.94] to 80.68% [SD 9.26]; P<.001). Conclusions: Improved glycemic outcomes were found across all pediatric age groups, including adolescents and very young children. These findings are in line with clinical trial results from commercially developed closed-loop systems.

KW - Artificial pancreas

KW - Automated insulin delivery

KW - Closed loop

KW - Diabetes

KW - Do it yourself

KW - Mobile health

KW - Open source

KW - Pediatric diabetes

KW - Type 1 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85071650910&partnerID=8YFLogxK

U2 - 10.2196/14087

DO - 10.2196/14087

M3 - Journal article

VL - 7

JO - J M I R mHealth and uHealth

JF - J M I R mHealth and uHealth

SN - 2291-5222

IS - 7

M1 - e14087

ER -

ID: 57811621