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Real-world evidence to guide healthcare policies in oncology

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@article{a584498affcb44bfbdd75d9227f1414a,
title = "Real-world evidence to guide healthcare policies in oncology",
abstract = "Randomized controlled clinical trials (RCTs) in oncology enroll patients who meet strict protocol-specified criteria. Many of these criteria overlap across multiple RCTs. A vast proportion of patients with metastatic cancer do not meet such criteria. Hence, patient populations encountered in clinical practice are essentially different from RCT-populations, questioning the representativeness of these trials. A real-world evidence approach, using data from clinical practice, is increasingly employed to complement the information on drug safety and efficacy obtained from traditional clinical trials.",
author = "Marco Donia and Hansen, {Steen Werner} and Svane, {Inge Marie}",
year = "2019",
month = "7",
day = "16",
doi = "10.18632/oncotarget.27077",
language = "English",
volume = "10",
pages = "4513--4515",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals LLC",
number = "44",

}

RIS

TY - JOUR

T1 - Real-world evidence to guide healthcare policies in oncology

AU - Donia, Marco

AU - Hansen, Steen Werner

AU - Svane, Inge Marie

PY - 2019/7/16

Y1 - 2019/7/16

N2 - Randomized controlled clinical trials (RCTs) in oncology enroll patients who meet strict protocol-specified criteria. Many of these criteria overlap across multiple RCTs. A vast proportion of patients with metastatic cancer do not meet such criteria. Hence, patient populations encountered in clinical practice are essentially different from RCT-populations, questioning the representativeness of these trials. A real-world evidence approach, using data from clinical practice, is increasingly employed to complement the information on drug safety and efficacy obtained from traditional clinical trials.

AB - Randomized controlled clinical trials (RCTs) in oncology enroll patients who meet strict protocol-specified criteria. Many of these criteria overlap across multiple RCTs. A vast proportion of patients with metastatic cancer do not meet such criteria. Hence, patient populations encountered in clinical practice are essentially different from RCT-populations, questioning the representativeness of these trials. A real-world evidence approach, using data from clinical practice, is increasingly employed to complement the information on drug safety and efficacy obtained from traditional clinical trials.

U2 - 10.18632/oncotarget.27077

DO - 10.18632/oncotarget.27077

M3 - Journal article

VL - 10

SP - 4513

EP - 4515

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

IS - 44

ER -

ID: 57727604