Real-world Pattern-of-Care Analysis of Cutaneous Lymphomas Radiotherapy Among EORTC Members

Khaled Elsayad; Emmanuella Guenova; Beatrice Fournier; Carolina Fernandes; Enrico Clementel; Evangelia Papadavid; Marie Beylot Barry; Felix Pavlotsky; Lena Specht; Mario Levis; Stephen Morris; Belinda Campbell; Jan P Nicolay; Richard Cowan; Dora Correia; Chalid Assaf; Pablo L Ortiz-Romero; Vassilis Kouloulias; Adele de Masson; Stephane Dalle; Pierre Clavère; Max Schlaak; Nina Booken; Marion Wobser; Christina Mitteldorf; Barzilai Aviv; Virgínia Mareco; Fernando Gallardo; Reinhard Dummer; Markus Gross; Felix Ehret; Andrea Lancia; Bartłomiej Tomasik; Lorna Hawley; Vincent Rermouchamps; Mona Abdel-Halim Ibrahim; Ahmed Gawish; Mohamed Abouegylah; Martin Stuschke; Adinda Baten; Hans Theodor Eich; EORTC cutaneous lymphoma study group

doi:10.1016/j.ijrobp.2024.11.011

Real-world Pattern-of-Care Analysis of Cutaneous Lymphomas Radiotherapy Among EORTC Members

Khaled Elsayad^*, Emmanuella Guenova, Beatrice Fournier, Carolina Fernandes, Enrico Clementel, Evangelia Papadavid, Marie Beylot Barry, Felix Pavlotsky, Lena Specht, Mario Levis, Stephen Morris, Belinda Campbell, Jan P Nicolay, Richard Cowan, Dora Correia, Chalid Assaf, Pablo L Ortiz-Romero, Vassilis Kouloulias, Adele de Masson, Stephane DallePierre Clavère, Max Schlaak, Nina Booken, Marion Wobser, Christina Mitteldorf, Barzilai Aviv, Virgínia Mareco, Fernando Gallardo, Reinhard Dummer, Markus Gross, Felix Ehret, Andrea Lancia, Bartłomiej Tomasik, Lorna Hawley, Vincent Rermouchamps, Mona Abdel-Halim Ibrahim, Ahmed Gawish, Mohamed Abouegylah, Martin Stuschke, Adinda Baten, Hans Theodor Eich, EORTC cutaneous lymphoma study group

^*Corresponding author af dette arbejde

Afdeling for Kræftbehandling

Abstract

PURPOSE: We aim to determine the current treatment patterns and recommendations among physicians for cutaneous lymphomas and to identify the types of skin lymphomas for which existing radiation regimens need improvement.

MATERIALS/METHODS: A questionnaire from the European Organisation for Research and Treatment of Cancer (EORTC) was distributed to all members of the Cutaneous Lymphoma Tumour Group and radiation oncology scintific council. This online survey included 13 questions regarding treatment practices for patients with cutaneous lymphoma. The survey was conducted from August 21 to December 18, 2023. Frequency distributions and subgroup comparisons were calculated and analyzed.

RESULTS: We collected 51 completed questionnaires from investigators from 19 countries specializing in cutaneous lymphoma treatment. Radiation doses varied significantly (range, 4-60 Gy). Based on the histologic entity, up to one-third of the investigators delivered hypofractionated regimens (range, 14% - 35%). Reduced-dose radiotherapy was considered by 27% to 63% of investigators. Meanwhile, 18 (35%) investigators considered adapting the radiation dose to the response to immunochemotherapy when treating primary cutaneous diffuse large B-cell lymphomal-leg type. Regarding total skin electron beam therapy, 91% of centres delivered reduced-dose regimens, and 18% of investigators applied ultra-hypofractionated protocols.

CONCLUSION: Radiotherapy of cutaneous lymphoma patients is highly heterogeneous among EORTC centres. Development of evidence-based recommendations for radiotherapy dose, fractionation, and technique for cutaneous lymphomas is required for optimization and standardization of treatment.

Originalsprog	Engelsk
Tidsskrift	International journal of radiation oncology, biology, physics
ISSN	0360-3016
DOI	https://doi.org/10.1016/j.ijrobp.2024.11.011
Status	E-pub ahead of print - 14 nov. 2024

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10.1016/j.ijrobp.2024.11.011

Citationsformater

Elsayad, K., Guenova, E., Fournier, B., Fernandes, C., Clementel, E., Papadavid, E., Barry, M. B., Pavlotsky, F., Specht, L., Levis, M., Morris, S., Campbell, B., Nicolay, J. P., Cowan, R., Correia, D., Assaf, C., Ortiz-Romero, P. L., Kouloulias, V., de Masson, A., ... EORTC cutaneous lymphoma study group (2024). Real-world Pattern-of-Care Analysis of Cutaneous Lymphomas Radiotherapy Among EORTC Members. International journal of radiation oncology, biology, physics. Advance online publication. https://doi.org/10.1016/j.ijrobp.2024.11.011

Elsayad, K, Guenova, E, Fournier, B, Fernandes, C, Clementel, E, Papadavid, E, Barry, MB, Pavlotsky, F, Specht, L, Levis, M, Morris, S, Campbell, B, Nicolay, JP, Cowan, R, Correia, D, Assaf, C, Ortiz-Romero, PL, Kouloulias, V, de Masson, A, Dalle, S, Clavère, P, Schlaak, M, Booken, N, Wobser, M, Mitteldorf, C, Aviv, B, Mareco, V, Gallardo, F, Dummer, R, Gross, M, Ehret, F, Lancia, A, Tomasik, B, Hawley, L, Rermouchamps, V, Ibrahim, MA-H, Gawish, A, Abouegylah, M, Stuschke, M, Baten, A, Eich, HT & EORTC cutaneous lymphoma study group 2024, 'Real-world Pattern-of-Care Analysis of Cutaneous Lymphomas Radiotherapy Among EORTC Members', International journal of radiation oncology, biology, physics. https://doi.org/10.1016/j.ijrobp.2024.11.011

@article{c36ec7c384dd40b189ee57d2fb05d78b,

title = "Real-world Pattern-of-Care Analysis of Cutaneous Lymphomas Radiotherapy Among EORTC Members",

abstract = "PURPOSE: We aim to determine the current treatment patterns and recommendations among physicians for cutaneous lymphomas and to identify the types of skin lymphomas for which existing radiation regimens need improvement.MATERIALS/METHODS: A questionnaire from the European Organisation for Research and Treatment of Cancer (EORTC) was distributed to all members of the Cutaneous Lymphoma Tumour Group and radiation oncology scintific council. This online survey included 13 questions regarding treatment practices for patients with cutaneous lymphoma. The survey was conducted from August 21 to December 18, 2023. Frequency distributions and subgroup comparisons were calculated and analyzed.RESULTS: We collected 51 completed questionnaires from investigators from 19 countries specializing in cutaneous lymphoma treatment. Radiation doses varied significantly (range, 4-60 Gy). Based on the histologic entity, up to one-third of the investigators delivered hypofractionated regimens (range, 14% - 35%). Reduced-dose radiotherapy was considered by 27% to 63% of investigators. Meanwhile, 18 (35%) investigators considered adapting the radiation dose to the response to immunochemotherapy when treating primary cutaneous diffuse large B-cell lymphomal-leg type. Regarding total skin electron beam therapy, 91% of centres delivered reduced-dose regimens, and 18% of investigators applied ultra-hypofractionated protocols.CONCLUSION: Radiotherapy of cutaneous lymphoma patients is highly heterogeneous among EORTC centres. Development of evidence-based recommendations for radiotherapy dose, fractionation, and technique for cutaneous lymphomas is required for optimization and standardization of treatment.",

author = "Khaled Elsayad and Emmanuella Guenova and Beatrice Fournier and Carolina Fernandes and Enrico Clementel and Evangelia Papadavid and Barry, {Marie Beylot} and Felix Pavlotsky and Lena Specht and Mario Levis and Stephen Morris and Belinda Campbell and Nicolay, {Jan P} and Richard Cowan and Dora Correia and Chalid Assaf and Ortiz-Romero, {Pablo L} and Vassilis Kouloulias and {de Masson}, Adele and Stephane Dalle and Pierre Clav{\`e}re and Max Schlaak and Nina Booken and Marion Wobser and Christina Mitteldorf and Barzilai Aviv and Virg{\'i}nia Mareco and Fernando Gallardo and Reinhard Dummer and Markus Gross and Felix Ehret and Andrea Lancia and Bart{\l}omiej Tomasik and Lorna Hawley and Vincent Rermouchamps and Ibrahim, {Mona Abdel-Halim} and Ahmed Gawish and Mohamed Abouegylah and Martin Stuschke and Adinda Baten and Eich, {Hans Theodor} and {EORTC cutaneous lymphoma study group}",

note = "Copyright {\textcopyright} 2024. Published by Elsevier Inc.",

year = "2024",

month = nov,

day = "14",

doi = "10.1016/j.ijrobp.2024.11.011",

language = "English",

journal = "International journal of radiation oncology, biology, physics",

issn = "0360-3016",

publisher = "Elsevier Inc",

}

TY - JOUR

T1 - Real-world Pattern-of-Care Analysis of Cutaneous Lymphomas Radiotherapy Among EORTC Members

AU - Elsayad, Khaled

AU - Guenova, Emmanuella

AU - Fournier, Beatrice

AU - Fernandes, Carolina

AU - Clementel, Enrico

AU - Papadavid, Evangelia

AU - Barry, Marie Beylot

AU - Pavlotsky, Felix

AU - Specht, Lena

AU - Levis, Mario

AU - Morris, Stephen

AU - Campbell, Belinda

AU - Nicolay, Jan P

AU - Cowan, Richard

AU - Correia, Dora

AU - Assaf, Chalid

AU - Ortiz-Romero, Pablo L

AU - Kouloulias, Vassilis

AU - de Masson, Adele

AU - Dalle, Stephane

AU - Clavère, Pierre

AU - Schlaak, Max

AU - Booken, Nina

AU - Wobser, Marion

AU - Mitteldorf, Christina

AU - Aviv, Barzilai

AU - Mareco, Virgínia

AU - Gallardo, Fernando

AU - Dummer, Reinhard

AU - Gross, Markus

AU - Ehret, Felix

AU - Lancia, Andrea

AU - Tomasik, Bartłomiej

AU - Hawley, Lorna

AU - Rermouchamps, Vincent

AU - Ibrahim, Mona Abdel-Halim

AU - Gawish, Ahmed

AU - Abouegylah, Mohamed

AU - Stuschke, Martin

AU - Baten, Adinda

AU - Eich, Hans Theodor

AU - EORTC cutaneous lymphoma study group

PY - 2024/11/14

Y1 - 2024/11/14

N2 - PURPOSE: We aim to determine the current treatment patterns and recommendations among physicians for cutaneous lymphomas and to identify the types of skin lymphomas for which existing radiation regimens need improvement.MATERIALS/METHODS: A questionnaire from the European Organisation for Research and Treatment of Cancer (EORTC) was distributed to all members of the Cutaneous Lymphoma Tumour Group and radiation oncology scintific council. This online survey included 13 questions regarding treatment practices for patients with cutaneous lymphoma. The survey was conducted from August 21 to December 18, 2023. Frequency distributions and subgroup comparisons were calculated and analyzed.RESULTS: We collected 51 completed questionnaires from investigators from 19 countries specializing in cutaneous lymphoma treatment. Radiation doses varied significantly (range, 4-60 Gy). Based on the histologic entity, up to one-third of the investigators delivered hypofractionated regimens (range, 14% - 35%). Reduced-dose radiotherapy was considered by 27% to 63% of investigators. Meanwhile, 18 (35%) investigators considered adapting the radiation dose to the response to immunochemotherapy when treating primary cutaneous diffuse large B-cell lymphomal-leg type. Regarding total skin electron beam therapy, 91% of centres delivered reduced-dose regimens, and 18% of investigators applied ultra-hypofractionated protocols.CONCLUSION: Radiotherapy of cutaneous lymphoma patients is highly heterogeneous among EORTC centres. Development of evidence-based recommendations for radiotherapy dose, fractionation, and technique for cutaneous lymphomas is required for optimization and standardization of treatment.

AB - PURPOSE: We aim to determine the current treatment patterns and recommendations among physicians for cutaneous lymphomas and to identify the types of skin lymphomas for which existing radiation regimens need improvement.MATERIALS/METHODS: A questionnaire from the European Organisation for Research and Treatment of Cancer (EORTC) was distributed to all members of the Cutaneous Lymphoma Tumour Group and radiation oncology scintific council. This online survey included 13 questions regarding treatment practices for patients with cutaneous lymphoma. The survey was conducted from August 21 to December 18, 2023. Frequency distributions and subgroup comparisons were calculated and analyzed.RESULTS: We collected 51 completed questionnaires from investigators from 19 countries specializing in cutaneous lymphoma treatment. Radiation doses varied significantly (range, 4-60 Gy). Based on the histologic entity, up to one-third of the investigators delivered hypofractionated regimens (range, 14% - 35%). Reduced-dose radiotherapy was considered by 27% to 63% of investigators. Meanwhile, 18 (35%) investigators considered adapting the radiation dose to the response to immunochemotherapy when treating primary cutaneous diffuse large B-cell lymphomal-leg type. Regarding total skin electron beam therapy, 91% of centres delivered reduced-dose regimens, and 18% of investigators applied ultra-hypofractionated protocols.CONCLUSION: Radiotherapy of cutaneous lymphoma patients is highly heterogeneous among EORTC centres. Development of evidence-based recommendations for radiotherapy dose, fractionation, and technique for cutaneous lymphomas is required for optimization and standardization of treatment.

U2 - 10.1016/j.ijrobp.2024.11.011

DO - 10.1016/j.ijrobp.2024.11.011

M3 - Journal article

C2 - 39549760

SN - 0360-3016

JO - International journal of radiation oncology, biology, physics

JF - International journal of radiation oncology, biology, physics

ER -

Real-world Pattern-of-Care Analysis of Cutaneous Lymphomas Radiotherapy Among EORTC Members

Abstract

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