TY - JOUR
T1 - Real-world effectiveness of CDK 4/6 inhibitors in estrogen-positive metastatic breast cancer
AU - Gehrchen, Mathilde Louise
AU - Berg, Tobias
AU - Garly, Rasmus
AU - Jensen, Maj-Britt
AU - Eßer-Naumann, Saskia
AU - Rønlev, Jeanette Dupont
AU - Nielsen, Hanne Melgaard
AU - Knoop, Ann
AU - Kümler, Iben
PY - 2024/6/20
Y1 - 2024/6/20
N2 - BACKGROUND: Initial treatment for advanced ER-positive/HER2-negative breast cancer involves a CDK 4/6 inhibitor (CDK 4/6i). Recent overall survival (OS) analyses led the Danish Medical Council to exclude palbociclib as preferred option. This study aimed to evaluate the real-world effectiveness of abemaciclib, palbociclib, and ribociclib in a Danish context. Additionally, to compare the inhibitors to identify potential endpoint differences.MATERIAL AND METHODS: Patients undergoing first or second line CDK 4/6i treatments from January 1st, 2017, until December 31st, 2021 were included. The primary endpoint was progression free survival (PFS).RESULTS: Among 2069 Danish patients, 1554 received first line treatment, 515 received second line treatment. In first line, abemaciclib's median PFS was unreached; palbociclib had a median PFS of 32.0 months (95% CI: 28.9-35.3); ribociclib 42.4 months (95% CI: 35.1-52.9). First-line median OS was 37.8 months (95% CI: 32.5-NA); 49.7 months (95% CI: 44.7-54.1); and 54.4 months (95% CI: 47.9-NA) for abemaciclib, palbociclib and ribociclib, respectively. No significant differences in OS were observed, nor in PFS in second line.CONCLUSION: This study confirms first-line CDK 4/6i effectiveness, with abemaciclib and ribociclib showing prolonged PFS vs. palbociclib. This study could not confirm a ranking of the three CDK 4/6i.
AB - BACKGROUND: Initial treatment for advanced ER-positive/HER2-negative breast cancer involves a CDK 4/6 inhibitor (CDK 4/6i). Recent overall survival (OS) analyses led the Danish Medical Council to exclude palbociclib as preferred option. This study aimed to evaluate the real-world effectiveness of abemaciclib, palbociclib, and ribociclib in a Danish context. Additionally, to compare the inhibitors to identify potential endpoint differences.MATERIAL AND METHODS: Patients undergoing first or second line CDK 4/6i treatments from January 1st, 2017, until December 31st, 2021 were included. The primary endpoint was progression free survival (PFS).RESULTS: Among 2069 Danish patients, 1554 received first line treatment, 515 received second line treatment. In first line, abemaciclib's median PFS was unreached; palbociclib had a median PFS of 32.0 months (95% CI: 28.9-35.3); ribociclib 42.4 months (95% CI: 35.1-52.9). First-line median OS was 37.8 months (95% CI: 32.5-NA); 49.7 months (95% CI: 44.7-54.1); and 54.4 months (95% CI: 47.9-NA) for abemaciclib, palbociclib and ribociclib, respectively. No significant differences in OS were observed, nor in PFS in second line.CONCLUSION: This study confirms first-line CDK 4/6i effectiveness, with abemaciclib and ribociclib showing prolonged PFS vs. palbociclib. This study could not confirm a ranking of the three CDK 4/6i.
U2 - 10.1038/s44276-024-00070-w
DO - 10.1038/s44276-024-00070-w
M3 - Journal article
C2 - 39516670
SN - 2731-9377
VL - 2
JO - BJC Reports
JF - BJC Reports
IS - 1
M1 - 44
ER -