Rapid loss of specific antibodies after pneumococcal vaccination in patients with human immunodeficiency virus-1 infection

Henrik Nielsen*, Birgit Kvinesdal, Thomas L. Benfield, Jens D. Lundgren, Helle B. Konradsen

*Corresponding author af dette arbejde
51 Citationer (Scopus)

Abstract

Pneumococcal infections are frequently observed in patients with human immunodeficiency virus (HIV) infection and active immunization has been recommended as prophylaxis in this patient group. We studied 103 out-patients with asymptomatic or mildly symptomatic HIV infection with respect to specific IgG and IgG2 pneumococcal antibodies before and after vaccination with a 23-valent pneumococcal polysaccharide vaccine. A significant increase (> 2-fold) in IgG and IgG2 antibody levels was observed after 1 month in 69/103 patients (67%) with no correlation with the CD4 cell count at the time of vaccination. The response rate was not influenced by concurrent treatment with anti-retroviral monotherapy, or by age or gender. After immunization a strong correlation between IgG and IgG2 anti-pneumococcal antibodies was demonstrated. Nevertheless, 12 months after vaccination the specific antibody titres were not significantly different from pre-vaccination values. In conclusion, antibodies induced by pneumococcal vaccination in patients with HIV infection have a short duration. This raises the question as to whether vaccination will have any impact on clinical end-point in this group of patients.

OriginalsprogEngelsk
TidsskriftScandinavian Journal of Infectious Diseases
Vol/bind30
Udgave nummer6
Sider (fra-til)597-601
Antal sider5
ISSN0036-5548
DOI
StatusUdgivet - 1998
Udgivet eksterntJa

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