Rapid functional upregulation of vasocontractile endothelin ET(B) receptors in rat coronary arteries

Gry Freja Skovsted; Anne Fog Pedersen; Rikke Larsen; Majid Sheykhzade; Lars Edvinsson

doi:10.1016/j.lfs.2012.02.009

Rapid functional upregulation of vasocontractile endothelin ET(B) receptors in rat coronary arteries

Gry Freja Skovsted
, Anne Fog Pedersen
, Rikke Larsen
, Majid Sheykhzade
, Lars Edvinsson

17 Citationer (Scopus)

Abstract

Endothelin ET(B) receptors mediate under normal physiological conditions vasorelaxation in coronary arteries. However, vasocontractile ET(B) receptors appear in coronary arteries of ischemic heart disease patients. Interestingly, organ culture of isolated coronary arteries also induces upregulation of vasocontractile ET(B) receptors. This study examines the early time course and mechanism behind upregulation of contractile ET(B) receptors in isolated rat coronary arteries during short-term organ culture.

Originalsprog	Engelsk
Tidsskrift	Life Sciences
Vol/bind	91
Udgave nummer	13-14
Sider (fra-til)	593-9
Antal sider	7
ISSN	0024-3205
DOI	https://doi.org/10.1016/j.lfs.2012.02.009
Status	Udgivet - 2012

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10.1016/j.lfs.2012.02.009

Citationsformater

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title = "Rapid functional upregulation of vasocontractile endothelin ET(B) receptors in rat coronary arteries",

abstract = "Endothelin ET(B) receptors mediate under normal physiological conditions vasorelaxation in coronary arteries. However, vasocontractile ET(B) receptors appear in coronary arteries of ischemic heart disease patients. Interestingly, organ culture of isolated coronary arteries also induces upregulation of vasocontractile ET(B) receptors. This study examines the early time course and mechanism behind upregulation of contractile ET(B) receptors in isolated rat coronary arteries during short-term organ culture.",

author = "Skovsted, \{Gry Freja\} and Pedersen, \{Anne Fog\} and Rikke Larsen and Majid Sheykhzade and Lars Edvinsson",

year = "2012",

doi = "10.1016/j.lfs.2012.02.009",

language = "English",

volume = "91",

pages = "593--9",

journal = "Life Sciences",

issn = "0024-3205",

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number = "13-14",

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TY - JOUR

T1 - Rapid functional upregulation of vasocontractile endothelin ET(B) receptors in rat coronary arteries

AU - Skovsted, Gry Freja

AU - Pedersen, Anne Fog

AU - Larsen, Rikke

AU - Sheykhzade, Majid

AU - Edvinsson, Lars

PY - 2012

Y1 - 2012

N2 - Endothelin ET(B) receptors mediate under normal physiological conditions vasorelaxation in coronary arteries. However, vasocontractile ET(B) receptors appear in coronary arteries of ischemic heart disease patients. Interestingly, organ culture of isolated coronary arteries also induces upregulation of vasocontractile ET(B) receptors. This study examines the early time course and mechanism behind upregulation of contractile ET(B) receptors in isolated rat coronary arteries during short-term organ culture.

AB - Endothelin ET(B) receptors mediate under normal physiological conditions vasorelaxation in coronary arteries. However, vasocontractile ET(B) receptors appear in coronary arteries of ischemic heart disease patients. Interestingly, organ culture of isolated coronary arteries also induces upregulation of vasocontractile ET(B) receptors. This study examines the early time course and mechanism behind upregulation of contractile ET(B) receptors in isolated rat coronary arteries during short-term organ culture.

U2 - 10.1016/j.lfs.2012.02.009

DO - 10.1016/j.lfs.2012.02.009

M3 - Journal article

C2 - 22391414

SN - 0024-3205

VL - 91

SP - 593

EP - 599

JO - Life Sciences

JF - Life Sciences

IS - 13-14

ER -

Rapid functional upregulation of vasocontractile endothelin ET(B) receptors in rat coronary arteries

Abstract

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