Rapid functional upregulation of vasocontractile endothelin ET(B) receptors in rat coronary arteries

Gry Freja Skovsted, Anne Fog Pedersen, Rikke Larsen, Majid Sheykhzade, Lars Edvinsson

15 Citationer (Scopus)

Abstract

Endothelin ET(B) receptors mediate under normal physiological conditions vasorelaxation in coronary arteries. However, vasocontractile ET(B) receptors appear in coronary arteries of ischemic heart disease patients. Interestingly, organ culture of isolated coronary arteries also induces upregulation of vasocontractile ET(B) receptors. This study examines the early time course and mechanism behind upregulation of contractile ET(B) receptors in isolated rat coronary arteries during short-term organ culture.
OriginalsprogEngelsk
TidsskriftLife Sciences
Vol/bind91
Udgave nummer13-14
Sider (fra-til)593-9
Antal sider7
ISSN0024-3205
DOI
StatusUdgivet - 2012

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