Radiographic progression is associated with resolution of systemic inflammation in patients with axial spondylarthritis treated with tumor necrosis factor α inhibitors: A study of radiographic progression, inflammation on magnetic resonance imaging, and circulating biomarkers of inflammation, angiogenesis, and cartilage and bone turnover

Susanne Juhl Pedersen; Inge Juul Sørensen; Robert G W Lambert; Kay-Geert A Hermann; Patrick Garnero; Julia Sidenius Johansen; Ole Rintek Madsen; Annette Hansen; Michael Sejer Hansen; Gorm Thamsborg; Lis Smedegaard Andersen; Ole Majgaard; Anne Gitte Loft; Jon Erlendsson; Karsten H Asmussen; Anne Grethe Jurik; Jakob Møller; Maria Hasselquist; Dorrit Mikkelsen; Mikkel Østergaard

doi:10.1002/art.30627

Radiographic progression is associated with resolution of systemic inflammation in patients with axial spondylarthritis treated with tumor necrosis factor α inhibitors: A study of radiographic progression, inflammation on magnetic resonance imaging, and circulating biomarkers of inflammation, angiogenesis, and cartilage and bone turnover

Susanne Juhl Pedersen, Inge Juul Sørensen, Robert G W Lambert, Kay-Geert A Hermann, Patrick Garnero, Julia Sidenius Johansen, Ole Rintek Madsen, Annette Hansen, Michael Sejer Hansen, Gorm Thamsborg, Lis Smedegaard Andersen, Ole Majgaard, Anne Gitte Loft, Jon Erlendsson, Karsten H Asmussen, Anne Grethe Jurik, Jakob Møller, Maria Hasselquist, Dorrit Mikkelsen, Mikkel Østergaard

Bispebjerg og Frederiksberg Hospital

88 Citationer (Scopus)

Abstract

To investigate the relationship of circulating biomarkers of inflammation (C-reactive protein [CRP], interleukin-6 [IL-6], and YKL-40), angiogenesis (vascular endothelial growth factor), cartilage turnover (C-terminal crosslinking telopeptide of type II collagen [CTX-II], total aggrecan, matrix metalloproteinase 3 [MMP-3], and cartilage oligomeric matrix protein [COMP]), and bone turnover (CTX-I and osteocalcin) to inflammation on magnetic resonance imaging (MRI) and radiographic progression in patients with axial spondylarthritis (SpA) beginning tumor necrosis factor α (TNFα) inhibitor therapy.

Originalsprog	Engelsk
Tidsskrift	Arthritis & Rheumatism
Vol/bind	63
Udgave nummer	12
Sider (fra-til)	3789-800
Antal sider	12
ISSN	0004-3591
DOI	https://doi.org/10.1002/art.30627
Status	Udgivet - 2011

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10.1002/art.30627

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Citationsformater

Pedersen, S. J., Sørensen, I. J., Lambert, R. G. W., Hermann, K.-G. A., Garnero, P., Johansen, J. S., Madsen, O. R., Hansen, A., Hansen, M. S., Thamsborg, G., Andersen, L. S., Majgaard, O., Loft, A. G., Erlendsson, J., Asmussen, K. H., Jurik, A. G., Møller, J., Hasselquist, M., Mikkelsen, D., & Østergaard, M. (2011). Radiographic progression is associated with resolution of systemic inflammation in patients with axial spondylarthritis treated with tumor necrosis factor α inhibitors: A study of radiographic progression, inflammation on magnetic resonance imaging, and circulating biomarkers of inflammation, angiogenesis, and cartilage and bone turnover. Arthritis & Rheumatism, 63(12), 3789-800. https://doi.org/10.1002/art.30627

Radiographic progression is associated with resolution of systemic inflammation in patients with axial spondylarthritis treated with tumor necrosis factor α inhibitors: A study of radiographic progression, inflammation on magnetic resonance imaging, and circulating biomarkers of inflammation, angiogenesis, and cartilage and bone turnover. / Pedersen, Susanne Juhl ; Sørensen, Inge Juul; Lambert, Robert G W et al.
I: Arthritis & Rheumatism, Bind 63, Nr. 12, 2011, s. 3789-800.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Pedersen, SJ , Sørensen, IJ, Lambert, RGW, Hermann, K-GA, Garnero, P, Johansen, JS , Madsen, OR , Hansen, A, Hansen, MS, Thamsborg, G, Andersen, LS, Majgaard, O, Loft, AG, Erlendsson, J, Asmussen, KH, Jurik, AG, Møller, J, Hasselquist, M, Mikkelsen, D & Østergaard, M 2011, 'Radiographic progression is associated with resolution of systemic inflammation in patients with axial spondylarthritis treated with tumor necrosis factor α inhibitors: A study of radiographic progression, inflammation on magnetic resonance imaging, and circulating biomarkers of inflammation, angiogenesis, and cartilage and bone turnover', Arthritis & Rheumatism, bind 63, nr. 12, s. 3789-800. https://doi.org/10.1002/art.30627

Pedersen SJ , Sørensen IJ, Lambert RGW, Hermann KGA, Garnero P, Johansen JS et al. Radiographic progression is associated with resolution of systemic inflammation in patients with axial spondylarthritis treated with tumor necrosis factor α inhibitors: A study of radiographic progression, inflammation on magnetic resonance imaging, and circulating biomarkers of inflammation, angiogenesis, and cartilage and bone turnover. Arthritis & Rheumatism. 2011;63(12):3789-800. doi: 10.1002/art.30627

Pedersen, Susanne Juhl ; Sørensen, Inge Juul ; Lambert, Robert G W et al. / Radiographic progression is associated with resolution of systemic inflammation in patients with axial spondylarthritis treated with tumor necrosis factor α inhibitors: A study of radiographic progression, inflammation on magnetic resonance imaging, and circulating biomarkers of inflammation, angiogenesis, and cartilage and bone turnover. I: Arthritis & Rheumatism. 2011 ; Bind 63, Nr. 12. s. 3789-800.

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abstract = "To investigate the relationship of circulating biomarkers of inflammation (C-reactive protein [CRP], interleukin-6 [IL-6], and YKL-40), angiogenesis (vascular endothelial growth factor), cartilage turnover (C-terminal crosslinking telopeptide of type II collagen [CTX-II], total aggrecan, matrix metalloproteinase 3 [MMP-3], and cartilage oligomeric matrix protein [COMP]), and bone turnover (CTX-I and osteocalcin) to inflammation on magnetic resonance imaging (MRI) and radiographic progression in patients with axial spondylarthritis (SpA) beginning tumor necrosis factor α (TNFα) inhibitor therapy.",

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T1 - Radiographic progression is associated with resolution of systemic inflammation in patients with axial spondylarthritis treated with tumor necrosis factor α inhibitors: A study of radiographic progression, inflammation on magnetic resonance imaging, and circulating biomarkers of inflammation, angiogenesis, and cartilage and bone turnover

AU - Pedersen, Susanne Juhl

AU - Sørensen, Inge Juul

AU - Lambert, Robert G W

AU - Hermann, Kay-Geert A

AU - Garnero, Patrick

AU - Johansen, Julia Sidenius

AU - Madsen, Ole Rintek

AU - Hansen, Annette

AU - Hansen, Michael Sejer

AU - Thamsborg, Gorm

AU - Andersen, Lis Smedegaard

AU - Majgaard, Ole

AU - Loft, Anne Gitte

AU - Erlendsson, Jon

AU - Asmussen, Karsten H

AU - Jurik, Anne Grethe

AU - Møller, Jakob

AU - Hasselquist, Maria

AU - Mikkelsen, Dorrit

AU - Østergaard, Mikkel

PY - 2011

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N2 - To investigate the relationship of circulating biomarkers of inflammation (C-reactive protein [CRP], interleukin-6 [IL-6], and YKL-40), angiogenesis (vascular endothelial growth factor), cartilage turnover (C-terminal crosslinking telopeptide of type II collagen [CTX-II], total aggrecan, matrix metalloproteinase 3 [MMP-3], and cartilage oligomeric matrix protein [COMP]), and bone turnover (CTX-I and osteocalcin) to inflammation on magnetic resonance imaging (MRI) and radiographic progression in patients with axial spondylarthritis (SpA) beginning tumor necrosis factor α (TNFα) inhibitor therapy.

AB - To investigate the relationship of circulating biomarkers of inflammation (C-reactive protein [CRP], interleukin-6 [IL-6], and YKL-40), angiogenesis (vascular endothelial growth factor), cartilage turnover (C-terminal crosslinking telopeptide of type II collagen [CTX-II], total aggrecan, matrix metalloproteinase 3 [MMP-3], and cartilage oligomeric matrix protein [COMP]), and bone turnover (CTX-I and osteocalcin) to inflammation on magnetic resonance imaging (MRI) and radiographic progression in patients with axial spondylarthritis (SpA) beginning tumor necrosis factor α (TNFα) inhibitor therapy.

U2 - 10.1002/art.30627

DO - 10.1002/art.30627

M3 - Journal article

C2 - 22127697

SN - 0004-3591

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