Radiographic progression is associated with resolution of systemic inflammation in patients with axial spondylarthritis treated with tumor necrosis factor α inhibitors: A study of radiographic progression, inflammation on magnetic resonance imaging, and circulating biomarkers of inflammation, angiogenesis, and cartilage and bone turnover

Susanne Juhl Pedersen; Inge Juul Sørensen; Robert G W Lambert; Kay-Geert A Hermann; Patrick Garnero; Julia Sidenius Johansen; Ole Rintek Madsen; Annette Hansen; Michael Sejer Hansen; Gorm Thamsborg; Lis Smedegaard Andersen; Ole Majgaard; Anne Gitte Loft; Jon Erlendsson; Karsten H Asmussen; Anne Grethe Jurik; Jakob Møller; Maria Hasselquist; Dorrit Mikkelsen; Mikkel Østergaard

doi:10.1002/art.30627

Radiographic progression is associated with resolution of systemic inflammation in patients with axial spondylarthritis treated with tumor necrosis factor α inhibitors: A study of radiographic progression, inflammation on magnetic resonance imaging, and circulating biomarkers of inflammation, angiogenesis, and cartilage and bone turnover

Susanne Juhl Pedersen, Inge Juul Sørensen, Robert G W Lambert, Kay-Geert A Hermann, Patrick Garnero, Julia Sidenius Johansen, Ole Rintek Madsen, Annette Hansen, Michael Sejer Hansen, Gorm Thamsborg, Lis Smedegaard Andersen, Ole Majgaard, Anne Gitte Loft, Jon Erlendsson, Karsten H Asmussen, Anne Grethe Jurik, Jakob Møller, Maria Hasselquist, Dorrit Mikkelsen, Mikkel Østergaard

Bispebjerg og Frederiksberg Hospital

86 Citationer (Scopus)

Abstrakt

To investigate the relationship of circulating biomarkers of inflammation (C-reactive protein [CRP], interleukin-6 [IL-6], and YKL-40), angiogenesis (vascular endothelial growth factor), cartilage turnover (C-terminal crosslinking telopeptide of type II collagen [CTX-II], total aggrecan, matrix metalloproteinase 3 [MMP-3], and cartilage oligomeric matrix protein [COMP]), and bone turnover (CTX-I and osteocalcin) to inflammation on magnetic resonance imaging (MRI) and radiographic progression in patients with axial spondylarthritis (SpA) beginning tumor necrosis factor α (TNFα) inhibitor therapy.

Originalsprog	Engelsk
Tidsskrift	Arthritis & Rheumatism
Vol/bind	63
Udgave nummer	12
Sider (fra-til)	3789-800
Antal sider	12
ISSN	0004-3591
DOI	https://doi.org/10.1002/art.30627
Status	Udgivet - 2011

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10.1002/art.30627

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Citationsformater

Pedersen, S. J., Sørensen, I. J., Lambert, R. G. W., Hermann, K-G. A., Garnero, P., Johansen, J. S., Madsen, O. R., Hansen, A., Hansen, M. S., Thamsborg, G., Andersen, L. S., Majgaard, O., Loft, A. G., Erlendsson, J., Asmussen, K. H., Jurik, A. G., Møller, J., Hasselquist, M., Mikkelsen, D., & Østergaard, M. (2011). Radiographic progression is associated with resolution of systemic inflammation in patients with axial spondylarthritis treated with tumor necrosis factor α inhibitors: A study of radiographic progression, inflammation on magnetic resonance imaging, and circulating biomarkers of inflammation, angiogenesis, and cartilage and bone turnover. Arthritis & Rheumatism, 63(12), 3789-800. https://doi.org/10.1002/art.30627

Radiographic progression is associated with resolution of systemic inflammation in patients with axial spondylarthritis treated with tumor necrosis factor α inhibitors: A study of radiographic progression, inflammation on magnetic resonance imaging, and circulating biomarkers of inflammation, angiogenesis, and cartilage and bone turnover. / Pedersen, Susanne Juhl ; Sørensen, Inge Juul; Lambert, Robert G W et al.

I: Arthritis & Rheumatism, Bind 63, Nr. 12, 2011, s. 3789-800.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Pedersen, SJ , Sørensen, IJ, Lambert, RGW, Hermann, K-GA, Garnero, P, Johansen, JS , Madsen, OR , Hansen, A, Hansen, MS, Thamsborg, G, Andersen, LS, Majgaard, O, Loft, AG, Erlendsson, J, Asmussen, KH, Jurik, AG, Møller, J, Hasselquist, M, Mikkelsen, D & Østergaard, M 2011, 'Radiographic progression is associated with resolution of systemic inflammation in patients with axial spondylarthritis treated with tumor necrosis factor α inhibitors: A study of radiographic progression, inflammation on magnetic resonance imaging, and circulating biomarkers of inflammation, angiogenesis, and cartilage and bone turnover', Arthritis & Rheumatism, bind 63, nr. 12, s. 3789-800. https://doi.org/10.1002/art.30627

Pedersen SJ , Sørensen IJ, Lambert RGW, Hermann K-GA, Garnero P, Johansen JS et al. Radiographic progression is associated with resolution of systemic inflammation in patients with axial spondylarthritis treated with tumor necrosis factor α inhibitors: A study of radiographic progression, inflammation on magnetic resonance imaging, and circulating biomarkers of inflammation, angiogenesis, and cartilage and bone turnover. Arthritis & Rheumatism. 2011;63(12):3789-800. https://doi.org/10.1002/art.30627

Pedersen, Susanne Juhl ; Sørensen, Inge Juul ; Lambert, Robert G W et al. / Radiographic progression is associated with resolution of systemic inflammation in patients with axial spondylarthritis treated with tumor necrosis factor α inhibitors: A study of radiographic progression, inflammation on magnetic resonance imaging, and circulating biomarkers of inflammation, angiogenesis, and cartilage and bone turnover. I: Arthritis & Rheumatism. 2011 ; Bind 63, Nr. 12. s. 3789-800.

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abstract = "To investigate the relationship of circulating biomarkers of inflammation (C-reactive protein [CRP], interleukin-6 [IL-6], and YKL-40), angiogenesis (vascular endothelial growth factor), cartilage turnover (C-terminal crosslinking telopeptide of type II collagen [CTX-II], total aggrecan, matrix metalloproteinase 3 [MMP-3], and cartilage oligomeric matrix protein [COMP]), and bone turnover (CTX-I and osteocalcin) to inflammation on magnetic resonance imaging (MRI) and radiographic progression in patients with axial spondylarthritis (SpA) beginning tumor necrosis factor α (TNFα) inhibitor therapy.",

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T1 - Radiographic progression is associated with resolution of systemic inflammation in patients with axial spondylarthritis treated with tumor necrosis factor α inhibitors: A study of radiographic progression, inflammation on magnetic resonance imaging, and circulating biomarkers of inflammation, angiogenesis, and cartilage and bone turnover

AU - Pedersen, Susanne Juhl

AU - Sørensen, Inge Juul

AU - Lambert, Robert G W

AU - Hermann, Kay-Geert A

AU - Garnero, Patrick

AU - Johansen, Julia Sidenius

AU - Madsen, Ole Rintek

AU - Hansen, Annette

AU - Hansen, Michael Sejer

AU - Thamsborg, Gorm

AU - Andersen, Lis Smedegaard

AU - Majgaard, Ole

AU - Loft, Anne Gitte

AU - Erlendsson, Jon

AU - Asmussen, Karsten H

AU - Jurik, Anne Grethe

AU - Møller, Jakob

AU - Hasselquist, Maria

AU - Mikkelsen, Dorrit

AU - Østergaard, Mikkel

PY - 2011

Y1 - 2011

N2 - To investigate the relationship of circulating biomarkers of inflammation (C-reactive protein [CRP], interleukin-6 [IL-6], and YKL-40), angiogenesis (vascular endothelial growth factor), cartilage turnover (C-terminal crosslinking telopeptide of type II collagen [CTX-II], total aggrecan, matrix metalloproteinase 3 [MMP-3], and cartilage oligomeric matrix protein [COMP]), and bone turnover (CTX-I and osteocalcin) to inflammation on magnetic resonance imaging (MRI) and radiographic progression in patients with axial spondylarthritis (SpA) beginning tumor necrosis factor α (TNFα) inhibitor therapy.

AB - To investigate the relationship of circulating biomarkers of inflammation (C-reactive protein [CRP], interleukin-6 [IL-6], and YKL-40), angiogenesis (vascular endothelial growth factor), cartilage turnover (C-terminal crosslinking telopeptide of type II collagen [CTX-II], total aggrecan, matrix metalloproteinase 3 [MMP-3], and cartilage oligomeric matrix protein [COMP]), and bone turnover (CTX-I and osteocalcin) to inflammation on magnetic resonance imaging (MRI) and radiographic progression in patients with axial spondylarthritis (SpA) beginning tumor necrosis factor α (TNFα) inhibitor therapy.

U2 - 10.1002/art.30627

DO - 10.1002/art.30627

M3 - Journal article

C2 - 22127697

VL - 63

SP - 3789

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JO - Arthritis and Rheumatism

JF - Arthritis and Rheumatism

SN - 0004-3591

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