Radiographic progression is associated with resolution of systemic inflammation in patients with axial spondylarthritis treated with tumor necrosis factor α inhibitors: A study of radiographic progression, inflammation on magnetic resonance imaging, and circulating biomarkers of inflammation, angiogenesis, and cartilage and bone turnover

Susanne Juhl Pedersen, Inge Juul Sørensen, Robert G W Lambert, Kay-Geert A Hermann, Patrick Garnero, Julia Sidenius Johansen, Ole Rintek Madsen, Annette Hansen, Michael Sejer Hansen, Gorm Thamsborg, Lis Smedegaard Andersen, Ole Majgaard, Anne Gitte Loft, Jon Erlendsson, Karsten H Asmussen, Anne Grethe Jurik, Jakob Møller, Maria Hasselquist, Dorrit Mikkelsen, Mikkel Østergaard

86 Citationer (Scopus)

Abstrakt

To investigate the relationship of circulating biomarkers of inflammation (C-reactive protein [CRP], interleukin-6 [IL-6], and YKL-40), angiogenesis (vascular endothelial growth factor), cartilage turnover (C-terminal crosslinking telopeptide of type II collagen [CTX-II], total aggrecan, matrix metalloproteinase 3 [MMP-3], and cartilage oligomeric matrix protein [COMP]), and bone turnover (CTX-I and osteocalcin) to inflammation on magnetic resonance imaging (MRI) and radiographic progression in patients with axial spondylarthritis (SpA) beginning tumor necrosis factor α (TNFα) inhibitor therapy.
OriginalsprogEngelsk
TidsskriftArthritis & Rheumatism
Vol/bind63
Udgave nummer12
Sider (fra-til)3789-800
Antal sider12
ISSN0004-3591
DOI
StatusUdgivet - 2011

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