Radiobiological risk estimates of adverse events and secondary cancer for proton and photon radiation therapy of pediatric medulloblastoma

N Patrik Brodin; Per Martin Munck af Rosenschöld; Marianne C Aznar; Anne Kiil Berthelsen; Ivan Vogelius; Per Nilsson; Birgitta Lannering; Thomas Björk-Eriksson

doi:10.3109/0284186X.2011.582514

Radiobiological risk estimates of adverse events and secondary cancer for proton and photon radiation therapy of pediatric medulloblastoma

N Patrik Brodin, Per Martin Munck af Rosenschöld, Marianne C Aznar, Anne Kiil Berthelsen, Ivan Vogelius, Per Nilsson, Birgitta Lannering, Thomas Björk-Eriksson

Afdeling for Klinisk Fysiologi og Nuklearmedicin DIA

121 Citationer (Scopus)

Abstract

The aim of this model study was to estimate and compare the risk of radiation-induced adverse late effects in pediatric patients with medulloblastoma (MB) treated with either three-dimensional conformal radiotherapy (3D CRT), inversely-optimized arc therapy (RapidArc(®) (RA)) or spot-scanned intensity-modulated proton therapy (IMPT). The aim was also to find dose-volume toxicity parameters relevant to children undergoing RT to be used in the inverse planning of RA and IMPT, and to use in the risk estimations.

Originalsprog	Engelsk
Tidsskrift	Acta Oncologica
Vol/bind	50
Udgave nummer	6
Sider (fra-til)	806-16
Antal sider	11
ISSN	0284-186X
DOI	https://doi.org/10.3109/0284186X.2011.582514
Status	Udgivet - 2011

Adgang til dokumentet

10.3109/0284186X.2011.582514

Andre filer og links

Link to publication in Scopus

Citationsformater

@article{b97656417d4449a79e62605928b79f18,

title = "Radiobiological risk estimates of adverse events and secondary cancer for proton and photon radiation therapy of pediatric medulloblastoma",

abstract = "The aim of this model study was to estimate and compare the risk of radiation-induced adverse late effects in pediatric patients with medulloblastoma (MB) treated with either three-dimensional conformal radiotherapy (3D CRT), inversely-optimized arc therapy (RapidArc({\textregistered}) (RA)) or spot-scanned intensity-modulated proton therapy (IMPT). The aim was also to find dose-volume toxicity parameters relevant to children undergoing RT to be used in the inverse planning of RA and IMPT, and to use in the risk estimations.",

keywords = "Cerebellar Neoplasms, Child, Child, Preschool, Female, Humans, Male, Medulloblastoma, Models, Statistical, Neoplasms, Second Primary, Organs at Risk, Photons, Protons, Radiotherapy Planning, Computer-Assisted, Radiotherapy, Conformal, Radiotherapy, Intensity-Modulated, Risk Assessment, Treatment Outcome",

author = "Brodin, \{N Patrik\} and \{Munck af Rosensch{\"o}ld\}, \{Per Martin\} and Aznar, \{Marianne C\} and Berthelsen, \{Anne Kiil\} and Ivan Vogelius and Per Nilsson and Birgitta Lannering and Thomas Bj{\"o}rk-Eriksson",

year = "2011",

doi = "10.3109/0284186X.2011.582514",

language = "English",

volume = "50",

pages = "806--16",

journal = "Acta Oncologica",

issn = "0284-186X",

publisher = "Medical Journals Sweden AB",

number = "6",

}

TY - JOUR

T1 - Radiobiological risk estimates of adverse events and secondary cancer for proton and photon radiation therapy of pediatric medulloblastoma

AU - Brodin, N Patrik

AU - Munck af Rosenschöld, Per Martin

AU - Aznar, Marianne C

AU - Berthelsen, Anne Kiil

AU - Vogelius, Ivan

AU - Nilsson, Per

AU - Lannering, Birgitta

AU - Björk-Eriksson, Thomas

PY - 2011

Y1 - 2011

N2 - The aim of this model study was to estimate and compare the risk of radiation-induced adverse late effects in pediatric patients with medulloblastoma (MB) treated with either three-dimensional conformal radiotherapy (3D CRT), inversely-optimized arc therapy (RapidArc(®) (RA)) or spot-scanned intensity-modulated proton therapy (IMPT). The aim was also to find dose-volume toxicity parameters relevant to children undergoing RT to be used in the inverse planning of RA and IMPT, and to use in the risk estimations.

AB - The aim of this model study was to estimate and compare the risk of radiation-induced adverse late effects in pediatric patients with medulloblastoma (MB) treated with either three-dimensional conformal radiotherapy (3D CRT), inversely-optimized arc therapy (RapidArc(®) (RA)) or spot-scanned intensity-modulated proton therapy (IMPT). The aim was also to find dose-volume toxicity parameters relevant to children undergoing RT to be used in the inverse planning of RA and IMPT, and to use in the risk estimations.

KW - Cerebellar Neoplasms

KW - Child

KW - Child, Preschool

KW - Female

KW - Humans

KW - Male

KW - Medulloblastoma

KW - Models, Statistical

KW - Neoplasms, Second Primary

KW - Organs at Risk

KW - Photons

KW - Protons

KW - Radiotherapy Planning, Computer-Assisted

KW - Radiotherapy, Conformal

KW - Radiotherapy, Intensity-Modulated

KW - Risk Assessment

KW - Treatment Outcome

UR - https://www.scopus.com/pages/publications/79960485877

U2 - 10.3109/0284186X.2011.582514

DO - 10.3109/0284186X.2011.582514

M3 - Journal article

C2 - 21767178

SN - 0284-186X

VL - 50

SP - 806

EP - 816

JO - Acta Oncologica

JF - Acta Oncologica

IS - 6

ER -

Radiobiological risk estimates of adverse events and secondary cancer for proton and photon radiation therapy of pediatric medulloblastoma

Abstract

Adgang til dokumentet

Andre filer og links

Fingeraftryk

Citationsformater