Radiobiological risk estimates of adverse events and secondary cancer for proton and photon radiation therapy of pediatric medulloblastoma

N Patrik Brodin, Per Martin Munck af Rosenschöld, Marianne C Aznar, Anne Kiil Berthelsen, Ivan Vogelius, Per Nilsson, Birgitta Lannering, Thomas Björk-Eriksson

112 Citationer (Scopus)

Abstract

The aim of this model study was to estimate and compare the risk of radiation-induced adverse late effects in pediatric patients with medulloblastoma (MB) treated with either three-dimensional conformal radiotherapy (3D CRT), inversely-optimized arc therapy (RapidArc(®) (RA)) or spot-scanned intensity-modulated proton therapy (IMPT). The aim was also to find dose-volume toxicity parameters relevant to children undergoing RT to be used in the inverse planning of RA and IMPT, and to use in the risk estimations.
OriginalsprogEngelsk
TidsskriftActa Oncologica
Vol/bind50
Udgave nummer6
Sider (fra-til)806-16
Antal sider11
ISSN0284-186X
DOI
StatusUdgivet - 2011

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