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Radioactive Seed Localization or Wire-guided Localization of Nonpalpable Invasive and In Situ Breast Cancer: A Randomized, Multicenter, Open-label Trial

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  1. Response to Comment on "Polypropylene Mesh and Fertility"

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The S100A10 Pathway Mediates an Occult Hyperfibrinolytic Subtype in Trauma Patients

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  3. The S100A10 Pathway Mediates an Occult Hyperfibrinolytic Subtype in Trauma Patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Response to the Comment on "Should We Have a Little More Patience With the Conventional 2-Stage Hepatectomy?"

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  5. Bowel Obstruction and Ventral Hernia After Laparoscopic Versus Open Surgery for Rectal Cancer in A Randomized Trial (COLOR II)

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Age-related renal function decline in Fabry disease patients on enzyme replacement therapy: a longitudinal cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Relation between invasive hemodynamics and measured glomerular filtration rate by 51Cr-EDTA clearance in advanced heart failure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Collagen density regulates the activity of tumor-infiltrating T cells

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  4. Long-Term Risk of Heart Failure in Breast Cancer Patients After Adjuvant Chemotherapy With or Without Trastuzumab

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Peptide receptor radionuclide therapy in gastroenteropancreatic NEN G3: a multicenter cohort study

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Vis graf over relationer

OBJECTIVE: To compare the rate of positive resection margins between radioactive seed localization (RSL) and wire-guided localization (WGL) after breast conserving surgery (BCS).

BACKGROUND: WGL is the current standard for localization of nonpalpable breast lesions in BCS, but there are several difficulties related to the method.

METHODS: From January 1, 2014 to February 4, 2016, patients with nonpalpable invasive breast cancer or DCIS visible on ultrasound were enrolled in this randomized, multicenter, open-label clinical trial, and randomly assigned to RSL or WGL. The primary outcome was margin status after BCS. Secondary outcomes were duration of the surgical procedure, weight of surgical specimen, and patients' pain perception. Analyses were performed by intention-to-treat (ITT) and per protocol.

RESULTS: Out of 444 eligible patients, 413 lesions representing 409 patients were randomized; 207 to RSL and 206 to WGL. Twenty-three did not meet inclusion criteria, chose to withdraw, or had a change in surgical management and were excluded. The remaining 390 lesions constituted the ITT population. Here, resection margins were positive in 23 cases (11.8%) in the RSL group compared with 26 cases (13.3%) in the WGL group (P = 0.65). The per-protocol analysis revealed no difference in margin status (P = 0.62). There were no significant differences in the duration of the surgical procedure (P = 0.12), weight of the surgical specimen (P = 0.54) or the patients' pain perception (P = 0.28).

CONCLUSION: RSL offers a major logistic advantage, as localization can be done several days before surgery without any increase in positive resection margins compared with WGL.

OriginalsprogEngelsk
TidsskriftAnnals of Surgery
Vol/bind266
Udgave nummer1
Sider (fra-til)29-35
Antal sider7
ISSN0003-4932
DOI
StatusUdgivet - jul. 2017

ID: 52153257