TY - JOUR
T1 - Radiation-induced undifferentiated spindle cell sarcoma following high-dose-rate interstitial brachytherapy for tongue squamous cell carcinoma
AU - Uchimoto, Yuka
AU - Shimamoto, Hiroaki
AU - Takeshita, Ami
AU - Oya, Kaori
AU - Kishino, Mitsunobu
AU - Fukuda, Yasuo
AU - Toyosawa, Satoru
AU - Oda, Michio
AU - Ogawa, Kazuhiko
AU - Kreiborg, Sven
AU - Mallya, Sanjay M
AU - Murakami, Shumei
N1 - Copyright © 2022 Termedia.
PY - 2022/6
Y1 - 2022/6
N2 - High-dose-rate interstitial brachytherapy (HDR-ISBT) has recently come to be considered one of the most effective treatments for oral cancer. On the other hand, it is important to note that radiation therapy has some side effects. Especially, radiation-induced malignancy is probably the most serious complication affecting long-term survivors. We report a case of a radiation-induced undifferentiated spindle cell sarcoma that developed following HDR-ISBT for tongue squamous cell carcinoma (SCC). A 39-year-old woman with right tongue SCC underwent HDR-ISBT (60 Gy, 10 fractions, 8 days) treatment. Five years and one month later, a tumor had developed at the primary site. Surgery was performed for the tumor, which was histopathologically diagnosed as an undifferentiated spindle cell sarcoma. That was distinct from the squamous cell origin of the primary cancer. According to recently established criteria for radiation-induced malignancy, this case was classified as a radiation-induced sarcoma. A search of the literature revealed no previous report of radiation-induced malignancy following HDR-ISBT for tongue cancer.
AB - High-dose-rate interstitial brachytherapy (HDR-ISBT) has recently come to be considered one of the most effective treatments for oral cancer. On the other hand, it is important to note that radiation therapy has some side effects. Especially, radiation-induced malignancy is probably the most serious complication affecting long-term survivors. We report a case of a radiation-induced undifferentiated spindle cell sarcoma that developed following HDR-ISBT for tongue squamous cell carcinoma (SCC). A 39-year-old woman with right tongue SCC underwent HDR-ISBT (60 Gy, 10 fractions, 8 days) treatment. Five years and one month later, a tumor had developed at the primary site. Surgery was performed for the tumor, which was histopathologically diagnosed as an undifferentiated spindle cell sarcoma. That was distinct from the squamous cell origin of the primary cancer. According to recently established criteria for radiation-induced malignancy, this case was classified as a radiation-induced sarcoma. A search of the literature revealed no previous report of radiation-induced malignancy following HDR-ISBT for tongue cancer.
UR - http://www.scopus.com/inward/record.url?scp=85135621609&partnerID=8YFLogxK
U2 - 10.5114/jcb.2022.116149
DO - 10.5114/jcb.2022.116149
M3 - Journal article
C2 - 36199998
VL - 14
SP - 268
EP - 272
JO - Journal of contemporary brachytherapy
JF - Journal of contemporary brachytherapy
SN - 1689-832X
IS - 3
ER -