Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscle

Keyphrases

• Insulin Resistance 100%
• Glucose-stimulated Insulin Secretion 100%
• Dysregulated 100%
• Human Skeletal muscle 100%
• Rac1 100%
• Rac1 Signaling 100%
• Insulin 44%
• PAK1 44%
• Glucose Transport 33%
• Knock-in Mouse Model 22%
• Skeletal muscle 22%
• Diabetes 11%
• Obesity 11%
• Protein Expression 11%
• Human Insulin 11%
• Insulin Sensitivity 11%
• Glucose Tolerance 11%
• Muscle Cells 11%
• Phosphorylation 11%
• Downstream Targets 11%
• GLUT4 Translocation 11%
• Downstream Signaling 11%
• Pharmacological Inhibitors 11%
• Plasma Insulin 11%
• Kinase Activation 11%
• Soleus 11%
• Intralipid 11%
• Mouse Skeletal muscle 11%
• Cytoskeleton 11%
• Skeletal muscle Insulin Resistance 11%
• Cultured muscle 11%
• Extensor Digitorum Longus 11%
• GTPase Rac1 11%
• Insulin Tolerance 11%
• Rac1 Protein 11%
• High-fat Diet Mice 11%
• Glucose Injection 11%

Medicine and Dentistry

• Glucose Uptake 100%
• Skeletal Muscle 100%
• P21 Activated Kinase 50%
• Diabetes 16%
• Infusion 16%
• Protein Expression 16%
• Guanosine Triphosphatase 16%
• Glucose Tolerance 16%
• Insulin Resistance 16%
• Ex Vivo 16%
• Recombinant Human Insulin 16%
• Human Insulin 16%
• Glucose Transporter 4 16%
• Myocyte 16%
• Intralipid 16%
• Insulin Tolerance Test 16%
• Actin 16%
• Extensor Digitorum Longus Muscle 16%
• Cytoskeleton 16%
• Rac1 Protein 16%