Quinolones for sepsis. A protocol for a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis

Steven Kwasi Korang; Mathias Maagaard; Joshua Feinberg; Anders Perner; Christian Gluud; Janus C Jakobsen

doi:10.1111/aas.13418

Quinolones for sepsis. A protocol for a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis

Steven Kwasi Korang, Mathias Maagaard, Joshua Feinberg, Anders Perner, Christian Gluud, Janus C Jakobsen

3 Citationer (Scopus)

Abstract

BACKGROUND: Sepsis is a relatively common and deadly condition that constitutes a major challenge to the modern health care system. Quinolones are sometimes used in combination with beta-lactam antibiotics for sepsis, but no former systematic review has assessed the benefits and harms of quinolones in patients with sepsis.

METHODS: We will perform a systematic review with meta-analysis and trial sequential analysis including randomised clinical trials assessing the effects of quinolones as add on therapy to usual care in children and adults with sepsis. For the assessment of harms, we will also include quasi-randomised studies and observational studies identified during our searches for randomised clinical trials.

DISCUSSION: This systematic review will clarify if there is evidence to support quinolones being part of the standard treatment for sepsis.

Originalsprog	Engelsk
Tidsskrift	Acta Anaesthesiologica Scandinavica
Vol/bind	63
Udgave nummer	8
Sider (fra-til)	1113-1123
Antal sider	11
ISSN	0001-5172
DOI	https://doi.org/10.1111/aas.13418
Status	Udgivet - 28 jun. 2019

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10.1111/aas.13418

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title = "Quinolones for sepsis. A protocol for a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis",

abstract = "BACKGROUND: Sepsis is a relatively common and deadly condition that constitutes a major challenge to the modern health care system. Quinolones are sometimes used in combination with beta-lactam antibiotics for sepsis, but no former systematic review has assessed the benefits and harms of quinolones in patients with sepsis.METHODS: We will perform a systematic review with meta-analysis and trial sequential analysis including randomised clinical trials assessing the effects of quinolones as add on therapy to usual care in children and adults with sepsis. For the assessment of harms, we will also include quasi-randomised studies and observational studies identified during our searches for randomised clinical trials.DISCUSSION: This systematic review will clarify if there is evidence to support quinolones being part of the standard treatment for sepsis.",

keywords = "adults, children, quinolones, sepsis, septic shock, systematic review, Trial Sequential Analysis",

author = "Korang, {Steven Kwasi} and Mathias Maagaard and Joshua Feinberg and Anders Perner and Christian Gluud and Jakobsen, {Janus C}",

note = "{\textcopyright} 2019 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.",

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T1 - Quinolones for sepsis. A protocol for a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis

AU - Korang, Steven Kwasi

AU - Maagaard, Mathias

AU - Feinberg, Joshua

AU - Perner, Anders

AU - Gluud, Christian

AU - Jakobsen, Janus C

PY - 2019/6/28

Y1 - 2019/6/28

N2 - BACKGROUND: Sepsis is a relatively common and deadly condition that constitutes a major challenge to the modern health care system. Quinolones are sometimes used in combination with beta-lactam antibiotics for sepsis, but no former systematic review has assessed the benefits and harms of quinolones in patients with sepsis.METHODS: We will perform a systematic review with meta-analysis and trial sequential analysis including randomised clinical trials assessing the effects of quinolones as add on therapy to usual care in children and adults with sepsis. For the assessment of harms, we will also include quasi-randomised studies and observational studies identified during our searches for randomised clinical trials.DISCUSSION: This systematic review will clarify if there is evidence to support quinolones being part of the standard treatment for sepsis.

AB - BACKGROUND: Sepsis is a relatively common and deadly condition that constitutes a major challenge to the modern health care system. Quinolones are sometimes used in combination with beta-lactam antibiotics for sepsis, but no former systematic review has assessed the benefits and harms of quinolones in patients with sepsis.METHODS: We will perform a systematic review with meta-analysis and trial sequential analysis including randomised clinical trials assessing the effects of quinolones as add on therapy to usual care in children and adults with sepsis. For the assessment of harms, we will also include quasi-randomised studies and observational studies identified during our searches for randomised clinical trials.DISCUSSION: This systematic review will clarify if there is evidence to support quinolones being part of the standard treatment for sepsis.

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KW - septic shock

KW - systematic review

KW - Trial Sequential Analysis

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U2 - 10.1111/aas.13418

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JO - Acta Anaesthesiologica Scandinavica

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Quinolones for sepsis. A protocol for a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis

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