Quantitative PET of human urokinase-type plasminogen activator receptor with 64Cu-DOTA-AE105: implications for visualizing cancer invasion

Morten Persson; Jacob Madsen; Søren Østergaard; Mette Munk Jensen; Jesper Tranekjær Jørgensen; Karina Juhl; Charlotte Lehmann; Michael Ploug; Andreas Kjaer

doi:10.2967/jnumed.110.083386

Quantitative PET of human urokinase-type plasminogen activator receptor with 64Cu-DOTA-AE105: implications for visualizing cancer invasion

Morten Persson, Jacob Madsen, Søren Østergaard, Mette Munk Jensen, Jesper Tranekjær Jørgensen, Karina Juhl, Charlotte Lehmann, Michael Ploug, Andreas Kjaer

Afdeling for Klinisk Fysiologi og Nuklearmedicin

72 Citationer (Scopus)

Abstract

Expression levels of the urokinase-type plasminogen activator receptor (uPAR) represent an established biomarker for poor prognosis in a variety of human cancers. The objective of the present study was to explore whether noninvasive PET can be used to perform a quantitative assessment of expression levels of uPAR across different human cancer xenograft models in mice and to illustrate the clinical potential of uPAR PET in future settings for individualized therapy.

Originalsprog	Engelsk
Tidsskrift	Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Vol/bind	53
Udgave nummer	1
Sider (fra-til)	138-45
Antal sider	8
DOI	https://doi.org/10.2967/jnumed.110.083386
Status	Udgivet - 2012

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10.2967/jnumed.110.083386

Citationsformater

Persson, M., Madsen, J., Østergaard, S., Jensen, M. M., Jørgensen, J. T., Juhl, K., Lehmann, C., Ploug, M., & Kjaer, A. (2012). Quantitative PET of human urokinase-type plasminogen activator receptor with 64Cu-DOTA-AE105: implications for visualizing cancer invasion. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 53(1), 138-45. https://doi.org/10.2967/jnumed.110.083386

Quantitative PET of human urokinase-type plasminogen activator receptor with 64Cu-DOTA-AE105: implications for visualizing cancer invasion. / Persson, Morten; Madsen, Jacob; Østergaard, Søren et al.
I: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Bind 53, Nr. 1, 2012, s. 138-45.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Persson, M, Madsen, J, Østergaard, S, Jensen, MM, Jørgensen, JT, Juhl, K, Lehmann, C, Ploug, M & Kjaer, A 2012, 'Quantitative PET of human urokinase-type plasminogen activator receptor with 64Cu-DOTA-AE105: implications for visualizing cancer invasion', Journal of nuclear medicine : official publication, Society of Nuclear Medicine, bind 53, nr. 1, s. 138-45. https://doi.org/10.2967/jnumed.110.083386

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abstract = "Expression levels of the urokinase-type plasminogen activator receptor (uPAR) represent an established biomarker for poor prognosis in a variety of human cancers. The objective of the present study was to explore whether noninvasive PET can be used to perform a quantitative assessment of expression levels of uPAR across different human cancer xenograft models in mice and to illustrate the clinical potential of uPAR PET in future settings for individualized therapy.",

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AU - Jensen, Mette Munk

AU - Jørgensen, Jesper Tranekjær

AU - Juhl, Karina

AU - Lehmann, Charlotte

AU - Ploug, Michael

AU - Kjaer, Andreas

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AB - Expression levels of the urokinase-type plasminogen activator receptor (uPAR) represent an established biomarker for poor prognosis in a variety of human cancers. The objective of the present study was to explore whether noninvasive PET can be used to perform a quantitative assessment of expression levels of uPAR across different human cancer xenograft models in mice and to illustrate the clinical potential of uPAR PET in future settings for individualized therapy.

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Quantitative PET of human urokinase-type plasminogen activator receptor with 64Cu-DOTA-AE105: implications for visualizing cancer invasion

Abstract

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