Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Quantitative fluorescence angiography detects dynamic changes in gastric perfusion

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Simulation-based VATS resection of the five lung lobes: a technical skills test

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Recovery after laparoscopic parastomal hernia repair

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Enhanced recovery after abdominal wall reconstruction: a systematic review and meta-analysis

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. Entero-pancreatic hormone secretion, gastric emptying, and glucose absorption after frequently sampled meal tests

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Neurotensin secretion after Roux-en-Y gastric bypass, sleeve gastrectomy, and truncal vagotomy with pyloroplasty

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Intraspecific variation in thermal tolerance differs between tropical and temperate fishes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Valid and Reliable Assessment of Upper Respiratory Tract Specimen Collection Skills during the COVID-19 Pandemic

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

INTRODUCTION: The use of Indocyanine green (ICG) fluorescence angiography (ICG-FA) is an applied method to assess visceral perfusion during surgical procedures worldwide. Further development has entailed quantification of the fluorescence signal; however, whether quantified ICG-FA can detect intraoperative changes in perfusion after hemorrhage has not been investigated previously. In this study, we investigated whether a quantification method, developed and validated in our department (q-ICG), could detect changes in gastric perfusion induced by hemorrhage and resuscitation.

METHODS: Ten pigs were included in the study. Specific regions of interest of the stomach were chosen, and three q-ICG measurements of gastric perfusion obtained: 20 min after completion of the laparoscopic setup (baseline), after reducing the circulating blood volume by 30%, and after reinfusion of the withdrawn blood volume. Hemodynamic variables were recorded, and blood samples were collected every 10 min during the procedure.

RESULTS: The reduction in blood volume generated decreased gastric perfusion (q-ICG) from baseline (p = 0.023), and gastric perfusion subsequently increased (p < 0.001) after the reintroduction of the withdrawn blood volume. Cardiac output (CO) and mean arterial blood pressure (MAP) shifted correspondingly and the gastric perfusion correlated to CO (r = 0.575, p = 0.001) and MAP (r = 0.436, p = 0.018).

CONCLUSION: We present a novel study showing that the q-ICG method can detect dynamic changes in local tissue perfusion induced by hemorrhage and resuscitation. As regional gastrointestinal perfusion may be significantly reduced, while hemodynamic variables such as MAP or heart rate remain stable, q-ICG may provide an objective, non-invasive method for detecting regional early ischemia, strengthening surgical decision making.

OriginalsprogEngelsk
TidsskriftSurgical Endoscopy
Vol/bind35
Udgave nummer12
Sider (fra-til)6786-6795
Antal sider10
ISSN0930-2794
DOI
StatusUdgivet - dec. 2021

ID: 61411932