Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Quantitative Cellular Changes in the Thalamus of Patients with Multiple System Atrophy

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Progressive effects of sildenafil on visual processing in rats

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Acute exercise protects newly formed motor memories against rTMS-induced interference targeting primary motor cortex

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Transcranial Alternating Current Stimulation Has Frequency-Dependent Effects on Motor Learning in Healthy Humans

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Functional Neuroimaging in Disorders of Consciousness: Raising Awareness for Those with Decreased Awareness

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. TDP-43-specific Autoantibody Decline in Patients With Amyotrophic Lateral Sclerosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Is There a Correlation Between the Number of Brain Cells and IQ?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Author Correction: Assessment of brain reference genes for RT-qPCR studies in neurodegenerative diseases

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  4. Highly sensitive quantification of optic neuritis intrathecal biomarker CXCL13

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

The thalamus is a brain region consisting of anatomical and functional connections between various spinal, subcortical, and cortical regions, which has a putative role in the clinical manifestation of Multiple System Atrophy (MSA). Previous stereological studies have reported significant anatomical alterations in diverse brain regions of MSA patients, including the cerebral cortex, basal ganglia and white matter, but no quantitative studies have examined the thalamus. To establish the extent of thalamic involvement, we applied stereological methods to estimate the total number of neurons and glial cells (oligodendrocytes, astrocytes and microglia) as well as the volume in two thalamic sub-regions, the mediodorsal nucleus (MDT) and the anterior principal nucleus (APn), in brains from ten MSA patients and 11 healthy control subjects. Compared to healthy controls, MSA patients had significantly fewer neurons (26%) in the MDT, but not the APn. We also found significantly more astrocytes (32%) and microglia (54%) in the MDT, with no such changes in the APn. Finally, we saw no group differences in the total number of oligodendrocytes. Our findings show a region-specific loss of thalamic neurons that occurs without loss of oligodendrocytes, whereas thalamic microgliosis seems to occur alongside astrogliosis. These pathological changes in the thalamus may contribute to the cognitive impairment seen in most patients with MSA.

OriginalsprogEngelsk
TidsskriftNeuroscience
Vol/bind459
Sider (fra-til)142-152
Antal sider11
ISSN0306-4522
DOI
StatusUdgivet - 1 apr. 2021

ID: 64277179