Quantification of Human T-lymphotropic virus type I (HTLV-I) provirus load in a rural West African population: no enhancement of human immunodeficiency virus type 2 pathogenesis, but HTLV-I provirus load relates to mortality

K Ariyoshi; N Berry; F Cham; S Jaffar; M Schim van der Loeff; O Jobe; PT N'Gom; Olav Ditlevsen Larsen; S Andersson; P Aaby; H Whittle

Quantification of Human T-lymphotropic virus type I (HTLV-I) provirus load in a rural West African population: no enhancement of human immunodeficiency virus type 2 pathogenesis, but HTLV-I provirus load relates to mortality

K Ariyoshi, N Berry, F Cham, S Jaffar, M Schim van der Loeff, O Jobe, PT N'Gom, Olav Ditlevsen Larsen, S Andersson, P Aaby, H Whittle

Infektionsmedicinsk Afdeling

17 Citationer (Scopus)

Abstract

Human T-lymphotropic virus type I (HTLV-I) provirus load was examined in a cohort of a population in Guinea-Bissau among whom human immunodeficiency virus (HIV) type 2 is endemic. Geometric mean of HIV-2 RNA load among HTLV-I-coinfected subjects was significantly lower than that in subjects infected with HIV-2 alone (212 vs. 724 copies/mL; P=.02). Adjusted for age, sex, and HIV status, the risk of death increased with HTLV-I provirus load; mortality hazard ratio was 1.59 for each log10 increase in HTLV-I provirus copies (P=.038). There is no enhancing effect of HTLV-I coinfection on HIV-2 disease, but high HTLV-I provirus loads may contribute to mortality.

Originalsprog	Engelsk
Tidsskrift	Journal of Infectious Diseases
Vol/bind	188
Udgave nummer	11
Sider (fra-til)	1648-51
ISSN	0022-1899
Status	Udgivet - 2003

Adgang til dokumentet

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=14639534&query_hl=35&itool=pubmed_docsum

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Citationsformater

Ariyoshi, K., Berry, N., Cham, F., Jaffar, S., Schim van der Loeff, M., Jobe, O., N'Gom, PT., Larsen, O. D., Andersson, S., Aaby, P., & Whittle, H. (2003). Quantification of Human T-lymphotropic virus type I (HTLV-I) provirus load in a rural West African population: no enhancement of human immunodeficiency virus type 2 pathogenesis, but HTLV-I provirus load relates to mortality. Journal of Infectious Diseases, 188(11), 1648-51. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=14639534&query_hl=35&itool=pubmed_docsum

Quantification of Human T-lymphotropic virus type I (HTLV-I) provirus load in a rural West African population: no enhancement of human immunodeficiency virus type 2 pathogenesis, but HTLV-I provirus load relates to mortality. / Ariyoshi, K; Berry, N; Cham, F et al.
I: Journal of Infectious Diseases, Bind 188, Nr. 11, 2003, s. 1648-51.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Ariyoshi, K, Berry, N, Cham, F, Jaffar, S, Schim van der Loeff, M, Jobe, O, N'Gom, PT, Larsen, OD, Andersson, S, Aaby, P & Whittle, H 2003, 'Quantification of Human T-lymphotropic virus type I (HTLV-I) provirus load in a rural West African population: no enhancement of human immunodeficiency virus type 2 pathogenesis, but HTLV-I provirus load relates to mortality', Journal of Infectious Diseases, bind 188, nr. 11, s. 1648-51. <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=14639534&query_hl=35&itool=pubmed_docsum>

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title = "Quantification of Human T-lymphotropic virus type I (HTLV-I) provirus load in a rural West African population: no enhancement of human immunodeficiency virus type 2 pathogenesis, but HTLV-I provirus load relates to mortality",

abstract = "Human T-lymphotropic virus type I (HTLV-I) provirus load was examined in a cohort of a population in Guinea-Bissau among whom human immunodeficiency virus (HIV) type 2 is endemic. Geometric mean of HIV-2 RNA load among HTLV-I-coinfected subjects was significantly lower than that in subjects infected with HIV-2 alone (212 vs. 724 copies/mL; P=.02). Adjusted for age, sex, and HIV status, the risk of death increased with HTLV-I provirus load; mortality hazard ratio was 1.59 for each log10 increase in HTLV-I provirus copies (P=.038). There is no enhancing effect of HTLV-I coinfection on HIV-2 disease, but high HTLV-I provirus loads may contribute to mortality.",

author = "K Ariyoshi and N Berry and F Cham and S Jaffar and {Schim van der Loeff}, M and O Jobe and PT N'Gom and Larsen, {Olav Ditlevsen} and S Andersson and P Aaby and H Whittle",

year = "2003",

language = "English",

volume = "188",

pages = "1648--51",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

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T1 - Quantification of Human T-lymphotropic virus type I (HTLV-I) provirus load in a rural West African population: no enhancement of human immunodeficiency virus type 2 pathogenesis, but HTLV-I provirus load relates to mortality

AU - Ariyoshi, K

AU - Berry, N

AU - Cham, F

AU - Jaffar, S

AU - Schim van der Loeff, M

AU - Jobe, O

AU - N'Gom, PT

AU - Larsen, Olav Ditlevsen

AU - Andersson, S

AU - Aaby, P

AU - Whittle, H

PY - 2003

Y1 - 2003

N2 - Human T-lymphotropic virus type I (HTLV-I) provirus load was examined in a cohort of a population in Guinea-Bissau among whom human immunodeficiency virus (HIV) type 2 is endemic. Geometric mean of HIV-2 RNA load among HTLV-I-coinfected subjects was significantly lower than that in subjects infected with HIV-2 alone (212 vs. 724 copies/mL; P=.02). Adjusted for age, sex, and HIV status, the risk of death increased with HTLV-I provirus load; mortality hazard ratio was 1.59 for each log10 increase in HTLV-I provirus copies (P=.038). There is no enhancing effect of HTLV-I coinfection on HIV-2 disease, but high HTLV-I provirus loads may contribute to mortality.

AB - Human T-lymphotropic virus type I (HTLV-I) provirus load was examined in a cohort of a population in Guinea-Bissau among whom human immunodeficiency virus (HIV) type 2 is endemic. Geometric mean of HIV-2 RNA load among HTLV-I-coinfected subjects was significantly lower than that in subjects infected with HIV-2 alone (212 vs. 724 copies/mL; P=.02). Adjusted for age, sex, and HIV status, the risk of death increased with HTLV-I provirus load; mortality hazard ratio was 1.59 for each log10 increase in HTLV-I provirus copies (P=.038). There is no enhancing effect of HTLV-I coinfection on HIV-2 disease, but high HTLV-I provirus loads may contribute to mortality.

M3 - Journal article

SN - 0022-1899

VL - 188

SP - 1648

EP - 1651

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

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ER -