Quantification of fluorescence angiography: Toward a reliable intraoperative assessment of tissue perfusion - A narrative review

Christian Dam Lütken*, Michael P. Achiam, Jens Osterkamp, Morten B. Svendsen, Nikolaj Nerup

*Corresponding author af dette arbejde
40 Citationer (Scopus)

Abstract

Background: Accurate intraoperative assessments of tissue perfusion are essential in all forms of surgery. As traditional methods of perfusion assessments are not available during minimally invasive surgery, novel methods are required. Here, fluorescence angiography with indocyanine green has shown promising results. However, to secure objective and reproducible assessments, quantification of the fluorescent signal is essential (Q-ICG). This narrative review aims to provide an overview of the current status and applicability of Q-ICG for intraoperative perfusion assessment. Results: Both commercial and custom Q-ICG software solutions are available for intraoperative use; however, most studies on Q-ICG have performed post-operative analyses. Q-ICG can be divided into inflow parameters (ttp, t0, slope, and T1/2max) and intensity parameters (Fmax, PI, and DR). The intensity parameters appear unreliable in clinical settings. In comparison, inflow parameters, mainly slope, and T1/2max have had superior clinical performance. Conclusion: Intraoperative Q-ICG is clinically available; however, only feasibility studies have been performed, rendering an excellent usability score. Q-ICG in a post-operative setting could detect changes in perfusion following a range of interventions and reflect clinical endpoints, but only if based on inflow parameters. Thus, future studies should include the methodology outlined in this review, emphasizing the use of inflow parameters (slope or T1/2max), a mass-adjusted ICG dosing, and a fixed camera position.

OriginalsprogEngelsk
TidsskriftLangenbeck's Archives of Surgery
Vol/bind406
Udgave nummer2
Sider (fra-til)251-259
Antal sider9
ISSN1435-2443
DOI
StatusUdgivet - 2021

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