Quantiferon test for tuberculosis screening in sarcoidosis patients

Nils Milman; Bolette Søborg; Claus Bo Svendsen; Åse Bengård Andersen

doi:10.3109/00365548.2011.582141

Quantiferon test for tuberculosis screening in sarcoidosis patients

Nils Milman, Bolette Søborg, Claus Bo Svendsen, Åse Bengård Andersen

24 Citationer (Scopus)

Abstract

Tumour necrosis factor-alpha (TNF-α) inhibitors have been introduced in the treatment of refractory sarcoidosis. These biologics may reactivate latent tuberculosis infection (LTBI). Despite its known limitations, the tuberculin skin test (TST) is currently used for the diagnosis of LTBI in Danish sarcoidosis patients. We report the results of a screening using the interferon-gamma release assay (IGRA) QuantiFERON TB Gold (QFN) for the diagnosis of LTBI. We aimed to assess whether the QFN is reliable for diagnosing LTBI among sarcoidosis patients and if results are influenced by disease activity or immunosuppressive treatment.

Originalsprog	Engelsk
Tidsskrift	Scandinavian Journal of Infectious Diseases
Vol/bind	43
Udgave nummer	9
Sider (fra-til)	728-35
Antal sider	8
ISSN	0036-5548
DOI	https://doi.org/10.3109/00365548.2011.582141
Status	Udgivet - 2011

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10.3109/00365548.2011.582141

Citationsformater

@article{ab8680d11fda40259afee2eeac866582,

title = "Quantiferon test for tuberculosis screening in sarcoidosis patients",

abstract = "Tumour necrosis factor-alpha (TNF-α) inhibitors have been introduced in the treatment of refractory sarcoidosis. These biologics may reactivate latent tuberculosis infection (LTBI). Despite its known limitations, the tuberculin skin test (TST) is currently used for the diagnosis of LTBI in Danish sarcoidosis patients. We report the results of a screening using the interferon-gamma release assay (IGRA) QuantiFERON TB Gold (QFN) for the diagnosis of LTBI. We aimed to assess whether the QFN is reliable for diagnosing LTBI among sarcoidosis patients and if results are influenced by disease activity or immunosuppressive treatment.",

keywords = "Adult, Biological Agents, Clinical Laboratory Techniques, Humans, Immunoassay, Immunologic Factors, Male, Mass Screening, Middle Aged, Predictive Value of Tests, Prospective Studies, Sarcoidosis, Tuberculosis, Tumor Necrosis Factor-alpha",

author = "Nils Milman and Bolette S{\o}borg and Svendsen, {Claus Bo} and Andersen, {{\AA}se Beng{\aa}rd}",

year = "2011",

doi = "10.3109/00365548.2011.582141",

language = "English",

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journal = "Scandinavian Journal of Infectious Diseases",

issn = "0036-5548",

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TY - JOUR

T1 - Quantiferon test for tuberculosis screening in sarcoidosis patients

AU - Milman, Nils

AU - Søborg, Bolette

AU - Svendsen, Claus Bo

AU - Andersen, Åse Bengård

PY - 2011

Y1 - 2011

N2 - Tumour necrosis factor-alpha (TNF-α) inhibitors have been introduced in the treatment of refractory sarcoidosis. These biologics may reactivate latent tuberculosis infection (LTBI). Despite its known limitations, the tuberculin skin test (TST) is currently used for the diagnosis of LTBI in Danish sarcoidosis patients. We report the results of a screening using the interferon-gamma release assay (IGRA) QuantiFERON TB Gold (QFN) for the diagnosis of LTBI. We aimed to assess whether the QFN is reliable for diagnosing LTBI among sarcoidosis patients and if results are influenced by disease activity or immunosuppressive treatment.

AB - Tumour necrosis factor-alpha (TNF-α) inhibitors have been introduced in the treatment of refractory sarcoidosis. These biologics may reactivate latent tuberculosis infection (LTBI). Despite its known limitations, the tuberculin skin test (TST) is currently used for the diagnosis of LTBI in Danish sarcoidosis patients. We report the results of a screening using the interferon-gamma release assay (IGRA) QuantiFERON TB Gold (QFN) for the diagnosis of LTBI. We aimed to assess whether the QFN is reliable for diagnosing LTBI among sarcoidosis patients and if results are influenced by disease activity or immunosuppressive treatment.

KW - Adult

KW - Biological Agents

KW - Clinical Laboratory Techniques

KW - Humans

KW - Immunoassay

KW - Immunologic Factors

KW - Male

KW - Mass Screening

KW - Middle Aged

KW - Predictive Value of Tests

KW - Prospective Studies

KW - Sarcoidosis

KW - Tuberculosis

KW - Tumor Necrosis Factor-alpha

U2 - 10.3109/00365548.2011.582141

DO - 10.3109/00365548.2011.582141

M3 - Journal article

C2 - 21619424

SN - 0036-5548

VL - 43

SP - 728

EP - 735

JO - Scandinavian Journal of Infectious Diseases

JF - Scandinavian Journal of Infectious Diseases

IS - 9

ER -

Quantiferon test for tuberculosis screening in sarcoidosis patients

Abstract

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