TY - JOUR
T1 - Quality assessment of a placental perfusion protocol
AU - Mathiesen, Line
AU - Mose, Tina
AU - Mørck, Thit Juul
AU - Nielsen, Jeanette Kolstrup Søgaard
AU - Nielsen, Leif Kofoed
AU - Maroun, Lisa Leth
AU - Dziegiel, Morten Hanefeld
AU - Larsen, Lise Grupe
AU - Knudsen, Lisbeth Ehlert
N1 - Copyright 2010 Elsevier Inc. All rights reserved.
PY - 2010/8/1
Y1 - 2010/8/1
N2 - Validation of in vitro test systems using the modular approach with steps addressing reliability and relevance is an important aim when developing in vitro tests in e.g. reproductive toxicology. The ex vivo human placental perfusion system may be used for such validation, here presenting the placental perfusion model in Copenhagen including control substances. The positive control substance antipyrine shows no difference in transport regardless of perfusion media used or of terms of delivery (n=59, p
AB - Validation of in vitro test systems using the modular approach with steps addressing reliability and relevance is an important aim when developing in vitro tests in e.g. reproductive toxicology. The ex vivo human placental perfusion system may be used for such validation, here presenting the placental perfusion model in Copenhagen including control substances. The positive control substance antipyrine shows no difference in transport regardless of perfusion media used or of terms of delivery (n=59, p
U2 - 10.1016/j.reprotox.2010.01.006
DO - 10.1016/j.reprotox.2010.01.006
M3 - Journal article
C2 - 20096346
SN - 1873-1708
VL - 30
SP - 138
EP - 146
JO - Reproductive toxicology (Elmsford, N.Y.)
JF - Reproductive toxicology (Elmsford, N.Y.)
IS - 1
ER -