Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Pyrexia's effect on the CBG-cortisol thermocouple, rather than CBG cleavage, elevates the acute free cortisol response to TNF-α in humans

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Enlargement of the human adrenal zona fasciculata and chronic psychiatric illness - an autopsy-based study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Can acute stress be fatal? A systematic cross-disciplinary review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. Rehabilitation for improved cognition in patients with stress-related exhaustion disorder: RECO - a randomized clinical trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Mobilising patients with severe acquired brain injury in intensive care (MAWERIC) - Protocol for a randomised cross-over trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Diagnostic criteria of CNS infection in patients with external ventricular drainage after traumatic brain injury: a pilot study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Reliability of cerebral autoregulation using different measures of perfusion pressure in patients with subarachnoid hemorrhage

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Microbiome Compositions and Resistome Levels after Antibiotic Treatment of Critically Ill Patients: An Observational Cohort Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Corticosteroid-binding globulin (CBG) cleavage promotes local cortisol delivery in inflammation. Enzymatic cleavage of high-affinity CBG to low-affinity CBG (haCBG to laCBG) occurs at inflammatory sites and is now measurable in vivo; however, the time kinetics of haCBG depletion following an inflammatory stimulus is unknown. Hence our aim was to determine the immediate effect of the key pro-inflammatory cytokine TNF-α on CBG levels and cleavage. We performed a crossover study of 12 healthy males receiving a TNF-α versus saline infusion, measuring total CBG, haCBG, laCBG and free and total cortisol hourly for 6 h. There was no change in total CBG or haCBG levels in the first 6 h of inflammation between the groups, suggesting that CBG cleavage is not activated nor is hepatic CBG production affected by TNF-α in this time frame. There was an early increase in the ratio of free:total cortisol, in association with pyrexia. This accords with data indicating that CBG acts a thermocouple in vivo, increasing free cortisol levels independent of elastase-driven cleavage.

OriginalsprogEngelsk
TidsskriftStress: The International Journal on the Biology of Stress
Vol/bind20
Udgave nummer2
Sider (fra-til)183-188
Antal sider6
ISSN1025-3890
DOI
StatusUdgivet - mar. 2017

ID: 52406673