Purified and specific cytoplasmic pollen extract: a non-hormonal alternative for the treatment of menopausal symptoms

Andrea Genazzani, Nick Panay, Tommaso Simoncini, Herman Depypere, Alfred Mueck, Christian Egarter, Nicoletta Biglia, Tomas Fait, Martin Birkhaeuser, Sven O Skouby, Mark Brincat, Steven Goldstein, Xiangyan Ruan, Cuauhtémoc Celis-Gonzales, Santiago Palacios

Abstract

Research into non-hormonal, alternative therapies is necessary for women for whom menopausal hormone therapy is contraindicated or for women who do not wish to take hormones. This review focuses on one such non-hormonal option, namely, purified and specific cytoplasmic pollen extract, or PureCyTonin®. This extract has been evaluated in several preclinical and clinical studies, where it demonstrated its value as a safe and non-estrogenic alternative for menopause. This review presents the beneficial effects of PureCyTonin® in the treatment of menopausal symptoms (e.g. hot flushes) in healthy women, as well as in premenstrual syndrome. We discuss the mechanism of action of PureCyTonin®, an SSRI-'like' therapy. The lack of estrogenic effect demonstrated in preclinical studies suggests that PureCyTonin® may also be a suitable option for the management of menopausal symptoms in women with breast cancer.

OriginalsprogEngelsk
TidsskriftGynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
Vol/bind36
Udgave nummer3
Sider (fra-til)190-196
Antal sider7
ISSN0951-3590
DOI
StatusUdgivet - mar. 2020

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