TY - JOUR
T1 - Purified and specific cytoplasmic pollen extract
T2 - a non-hormonal alternative for the treatment of menopausal symptoms
AU - Genazzani, Andrea
AU - Panay, Nick
AU - Simoncini, Tommaso
AU - Depypere, Herman
AU - Mueck, Alfred
AU - Egarter, Christian
AU - Biglia, Nicoletta
AU - Fait, Tomas
AU - Birkhaeuser, Martin
AU - Skouby, Sven O
AU - Brincat, Mark
AU - Goldstein, Steven
AU - Ruan, Xiangyan
AU - Celis-Gonzales, Cuauhtémoc
AU - Palacios, Santiago
PY - 2020/3
Y1 - 2020/3
N2 - Research into non-hormonal, alternative therapies is necessary for women for whom menopausal hormone therapy is contraindicated or for women who do not wish to take hormones. This review focuses on one such non-hormonal option, namely, purified and specific cytoplasmic pollen extract, or PureCyTonin®. This extract has been evaluated in several preclinical and clinical studies, where it demonstrated its value as a safe and non-estrogenic alternative for menopause. This review presents the beneficial effects of PureCyTonin® in the treatment of menopausal symptoms (e.g. hot flushes) in healthy women, as well as in premenstrual syndrome. We discuss the mechanism of action of PureCyTonin®, an SSRI-'like' therapy. The lack of estrogenic effect demonstrated in preclinical studies suggests that PureCyTonin® may also be a suitable option for the management of menopausal symptoms in women with breast cancer.
AB - Research into non-hormonal, alternative therapies is necessary for women for whom menopausal hormone therapy is contraindicated or for women who do not wish to take hormones. This review focuses on one such non-hormonal option, namely, purified and specific cytoplasmic pollen extract, or PureCyTonin®. This extract has been evaluated in several preclinical and clinical studies, where it demonstrated its value as a safe and non-estrogenic alternative for menopause. This review presents the beneficial effects of PureCyTonin® in the treatment of menopausal symptoms (e.g. hot flushes) in healthy women, as well as in premenstrual syndrome. We discuss the mechanism of action of PureCyTonin®, an SSRI-'like' therapy. The lack of estrogenic effect demonstrated in preclinical studies suggests that PureCyTonin® may also be a suitable option for the management of menopausal symptoms in women with breast cancer.
KW - Antigens, Plant/therapeutic use
KW - Female
KW - Hot Flashes/drug therapy
KW - Humans
KW - Menopause
KW - Plant Extracts/therapeutic use
KW - Pollen
KW - Premenstrual Syndrome/drug therapy
KW - Vitamin E/therapeutic use
U2 - 10.1080/09513590.2020.1722994
DO - 10.1080/09513590.2020.1722994
M3 - Review
C2 - 32019391
SN - 0951-3590
VL - 36
SP - 190
EP - 196
JO - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
IS - 3
ER -