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Pupillary light responses in type 1 and type 2 diabetics with and without retinopathy

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@article{112734b5b95742c484470b4e3e6d549f,
title = "Pupillary light responses in type 1 and type 2 diabetics with and without retinopathy",
abstract = "OBJECTIVE: We assessed the function of rod/cones and melanopsin in type 1 (T1DM) and type 2 diabetes mellitus (T2DM) with and without non-proliferative diabetic retinopathy (NPDR).METHODS: We performed pupillometry on 22 healthy controls and four diabetic groups: 12 T1DM patients without NPDR and 12 with moderate NPDR, and 16 T2DM patients without NPDR and 12 with moderate NPDR. Monocular stimulations of 20 seconds with red (λ = 633 nm) and blue light (λ = 463 nm) at ~15 log quanta/cm2 /second were performed. The primary outcome was the melanopsin-mediated late redilation phase of postillumination pupillary light response (PIPRLate ) to blue light. The secondary outcomes were the mixed rod/cone and melanopsin responses, that is maximal pupil constriction and the early redilation phase of PIPR (PIPREarly ).RESULTS: Late redilation phase of PIPR (PIPRLate ) to blue and red light stimuli was not significantly different between healthy control and the four diabetic groups (n.s.). The maximal pupil contractions to blue light stimulus were significantly reduced in T1DM patients as well as in T2DM patients with NPDR (p ≤ 0.02), whereas for red light stimuli, the maximal pupil constriction was only reduced in T2DM with NPDR (p < 0.01). Early redilation phase of PIPR (PIPREarly ) to blue and red light stimuli was not significantly different between healthy controls and diabetic patients (n.s.).CONCLUSION: Neither the PIPREarly nor the PIPRLate was significantly reduced in diabetics with or without NPDR compared to healthy controls. The reduced maximal pupil constrictions in diabetics with NPDR indicate decreased mixed rod/cone and melanopsin responses.",
keywords = "cone, diabetic retinopathy, ipRGCs, melanopsin, pupillary light reflex, pupillometry",
author = "Shakoor Ba-Ali and Br{\o}ndsted, {Adam Elias} and Andersen, {Henrik Ullits} and Poul Jennum and Henrik Lund-Andersen",
note = "{\circledC} 2020 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.",
year = "2020",
month = "8",
day = "1",
doi = "10.1111/aos.14348",
language = "English",
volume = "98",
pages = "477--484",
journal = "Acta Ophthalmologica (Online)",
issn = "1755-3768",
publisher = "Wiley-Blackwell Publishing, Inc",
number = "5",

}

RIS

TY - JOUR

T1 - Pupillary light responses in type 1 and type 2 diabetics with and without retinopathy

AU - Ba-Ali, Shakoor

AU - Brøndsted, Adam Elias

AU - Andersen, Henrik Ullits

AU - Jennum, Poul

AU - Lund-Andersen, Henrik

N1 - © 2020 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

PY - 2020/8/1

Y1 - 2020/8/1

N2 - OBJECTIVE: We assessed the function of rod/cones and melanopsin in type 1 (T1DM) and type 2 diabetes mellitus (T2DM) with and without non-proliferative diabetic retinopathy (NPDR).METHODS: We performed pupillometry on 22 healthy controls and four diabetic groups: 12 T1DM patients without NPDR and 12 with moderate NPDR, and 16 T2DM patients without NPDR and 12 with moderate NPDR. Monocular stimulations of 20 seconds with red (λ = 633 nm) and blue light (λ = 463 nm) at ~15 log quanta/cm2 /second were performed. The primary outcome was the melanopsin-mediated late redilation phase of postillumination pupillary light response (PIPRLate ) to blue light. The secondary outcomes were the mixed rod/cone and melanopsin responses, that is maximal pupil constriction and the early redilation phase of PIPR (PIPREarly ).RESULTS: Late redilation phase of PIPR (PIPRLate ) to blue and red light stimuli was not significantly different between healthy control and the four diabetic groups (n.s.). The maximal pupil contractions to blue light stimulus were significantly reduced in T1DM patients as well as in T2DM patients with NPDR (p ≤ 0.02), whereas for red light stimuli, the maximal pupil constriction was only reduced in T2DM with NPDR (p < 0.01). Early redilation phase of PIPR (PIPREarly ) to blue and red light stimuli was not significantly different between healthy controls and diabetic patients (n.s.).CONCLUSION: Neither the PIPREarly nor the PIPRLate was significantly reduced in diabetics with or without NPDR compared to healthy controls. The reduced maximal pupil constrictions in diabetics with NPDR indicate decreased mixed rod/cone and melanopsin responses.

AB - OBJECTIVE: We assessed the function of rod/cones and melanopsin in type 1 (T1DM) and type 2 diabetes mellitus (T2DM) with and without non-proliferative diabetic retinopathy (NPDR).METHODS: We performed pupillometry on 22 healthy controls and four diabetic groups: 12 T1DM patients without NPDR and 12 with moderate NPDR, and 16 T2DM patients without NPDR and 12 with moderate NPDR. Monocular stimulations of 20 seconds with red (λ = 633 nm) and blue light (λ = 463 nm) at ~15 log quanta/cm2 /second were performed. The primary outcome was the melanopsin-mediated late redilation phase of postillumination pupillary light response (PIPRLate ) to blue light. The secondary outcomes were the mixed rod/cone and melanopsin responses, that is maximal pupil constriction and the early redilation phase of PIPR (PIPREarly ).RESULTS: Late redilation phase of PIPR (PIPRLate ) to blue and red light stimuli was not significantly different between healthy control and the four diabetic groups (n.s.). The maximal pupil contractions to blue light stimulus were significantly reduced in T1DM patients as well as in T2DM patients with NPDR (p ≤ 0.02), whereas for red light stimuli, the maximal pupil constriction was only reduced in T2DM with NPDR (p < 0.01). Early redilation phase of PIPR (PIPREarly ) to blue and red light stimuli was not significantly different between healthy controls and diabetic patients (n.s.).CONCLUSION: Neither the PIPREarly nor the PIPRLate was significantly reduced in diabetics with or without NPDR compared to healthy controls. The reduced maximal pupil constrictions in diabetics with NPDR indicate decreased mixed rod/cone and melanopsin responses.

KW - cone

KW - diabetic retinopathy

KW - ipRGCs

KW - melanopsin

KW - pupillary light reflex

KW - pupillometry

U2 - 10.1111/aos.14348

DO - 10.1111/aos.14348

M3 - Journal article

VL - 98

SP - 477

EP - 484

JO - Acta Ophthalmologica (Online)

JF - Acta Ophthalmologica (Online)

SN - 1755-3768

IS - 5

ER -

ID: 59167782