Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Pulmonary function and fitness years after treatment for hypersensitivity pneumonitis during childhood

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Tidal breath eNO measurements in a cohort of unsedated hospitalized neonates-A method validation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Individual pharmacokinetic variation leads to underdosing of ciprofloxacin in some cystic fibrosis patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Evaluation of a bovine antibody test for diagnosing Mycobacterium avium complex in patients with cystic fibrosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Exercise-induced inspiratory symptoms in school children

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Breathless and Young—In Need of Inspiration

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  1. Lung Scintigraphy in COPD

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. The accessibility of topical treatment in the paranasal sinuses on operated cystic fibrosis patients assessed by scintigraphy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Football training improves metabolic and cardiovascular health status in 55- to 70-year-old women and men with prediabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Osteogenic impact of football training in 55- to 70-year-old women and men with prediabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Hypersensitivity pneumonitis (HP) is an immune-mediated diffuse lung disease. Significant improvement in lung function and diffusing capacity after treatment was previously demonstrated, while long-term data focusing specifically on peripheral airway impairment and peak oxygen uptake (fitness) are lacking. Hence, the aim of this study was to conduct a comprehensive study to determine the stability of pulmonary function and fitness in patients previously diagnosed with HP.

METHODS: We performed a cross-sectional follow-up study with inclusion of longitudinal data if available in patients previously diagnosed with biopsy and high-resolution computed tomography-verified HP during childhood. We performed multiple breath wash-out (LCI2.5 ), spirometry (FEV1 ), bronchiodilator responsiveness test, diffusing capacity (DLCO and DLCO /VA ), body-plethysmography (TLC), and peak oxygen uptake (VO2peak ). St. George Respiratory Questionnaire was used as a measure of respiratory quality of life.

RESULTS: Twenty two patients were assessed. LCI2.5 was abnormal in 47.4% compared to abnormal FEV1 in only 9.1% and without significant bronchiodilator responsiveness. DLCO and TLC were abnormal in 40.9 and 13.6%, respectively, while DLCO /VA was within normal range. Only 11.1% demonstrated abnormal VO2peak . All longitudinally assessed outcomes remained unchanged between end of treatment and time of follow up.

CONCLUSIONS: A large proportion of patients previously diagnosed with HP had abnormal LCI2.5 in contrast to normal spirometry. Spirometric outcomes, TLC, and diffusing capacity were persistently slightly reduced, but stable, and VO2peak was excellent at time of follow-up. Long-term prognosis in children with HP appears favorable although persistent peripheral airway involvement of unknown clinical significance was demonstrated in almost half of the patients. Pediatr Pulmonol. © 2015 Wiley Periodicals, Inc.

OriginalsprogEngelsk
TidsskriftPediatric Pulmonology
Vol/bind51
Udgave nummer8
Sider (fra-til)830-7
ISSN8755-6863
DOI
StatusUdgivet - 2016

ID: 46269951