TY - JOUR
T1 - Pulmonary Arterial Enlargement in Well-Treated Persons With Human Immunodeficiency Virus
AU - Knudsen, Andreas D
AU - Ronit, Andreas
AU - Kristensen, Thomas
AU - Thomsen, Magda Teresa
AU - Lebech, Anne-Mette
AU - Pham, Michael Huy Cuong
AU - Sigvardsen, Per
AU - KÜhl, Jørgen Tobias
AU - Fuchs, Andreas
AU - Køber, Lars
AU - Lundgren, Jens
AU - Vestbo, Jørgen
AU - Kofoed, Klaus F
AU - Nielsen, Susanne D
N1 - © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Background: Pulmonary artery enlargement is a marker of pulmonary hypertension. We aimed to determine the proportion with pulmonary artery enlargement among well-treated persons with human immunodeficiency virus HIV (PWH) and uninfected controls. Methods: PWH with a chest computed tomography were included from the ongoing Copenhagen Comorbidity in HIV Infection (COCOMO) study. Age and sex-matched uninfected controls were recruited from the Copenhagen General Population Study. Pulmonary artery enlargement was defined as a ratio of >1 between the diameter of the main pulmonary artery (at the level of its bifurcation) and the diameter of the ascending aorta. Results: In total, 900 PWH were included, and 44 (5%) had a pulmonary artery-aorta ratio (PA:A) >1. After adjustment for age, sex, and body mass index, obesity (adjusted odds ratio, 4.33; 95% confidence interval, 1.76-10.65; P =. 001) and injection drug use (IDU) (4.90; 1.00-18.46; P =. 03) were associated with higher odds of having a PA:A >1, and pulmonary indices and smoking status were not. HIV seropositivity was borderline associated with a PA:A >1 (adjusted odds ratio, 1.89; 95% confidence interval,. 92-3.85; P =. 08). Conclusions: A PA:A >1 was common in PWH. Obesity and IDU were independently associated with this finding and HIV serostatus was borderline associated with it, but HIV-related factors were not. Increased awareness may be appropriate in obese PWH and those with IDU.
AB - Background: Pulmonary artery enlargement is a marker of pulmonary hypertension. We aimed to determine the proportion with pulmonary artery enlargement among well-treated persons with human immunodeficiency virus HIV (PWH) and uninfected controls. Methods: PWH with a chest computed tomography were included from the ongoing Copenhagen Comorbidity in HIV Infection (COCOMO) study. Age and sex-matched uninfected controls were recruited from the Copenhagen General Population Study. Pulmonary artery enlargement was defined as a ratio of >1 between the diameter of the main pulmonary artery (at the level of its bifurcation) and the diameter of the ascending aorta. Results: In total, 900 PWH were included, and 44 (5%) had a pulmonary artery-aorta ratio (PA:A) >1. After adjustment for age, sex, and body mass index, obesity (adjusted odds ratio, 4.33; 95% confidence interval, 1.76-10.65; P =. 001) and injection drug use (IDU) (4.90; 1.00-18.46; P =. 03) were associated with higher odds of having a PA:A >1, and pulmonary indices and smoking status were not. HIV seropositivity was borderline associated with a PA:A >1 (adjusted odds ratio, 1.89; 95% confidence interval,. 92-3.85; P =. 08). Conclusions: A PA:A >1 was common in PWH. Obesity and IDU were independently associated with this finding and HIV serostatus was borderline associated with it, but HIV-related factors were not. Increased awareness may be appropriate in obese PWH and those with IDU.
KW - Computed Tomography
KW - HCV co-infection
KW - HIV
KW - Persons With HIV
KW - Pulmonary Arterial Enlargement
KW - Pulmonary Hypertension
KW - computed tomography
KW - persons with HIV
KW - HCV coinfection
KW - pulmonary hypertension
KW - pulmonary arterial enlargement
UR - http://www.scopus.com/inward/record.url?scp=85099428108&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiaa339
DO - 10.1093/infdis/jiaa339
M3 - Journal article
C2 - 32561921
SN - 0022-1899
VL - 223
SP - 94
EP - 100
JO - The Journal of infectious diseases
JF - The Journal of infectious diseases
IS - 1
M1 - jiaa339
ER -