Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Pubertal Progression and Reproductive Hormones in Healthy Girls with Transient Thelarche

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Evaluation of Serum Insulin-like Factor 3 Quantification by LC-MS/MS as a Biomarker of Leydig Cell Function

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Genetic variation at PPP1R3B increases hepatic CT attenuation and interacts with prandial status on plasma glucose

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Increases in bioactive IGF do not parallel increases in total IGF-I during growth hormone treatment of children born SGA

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Muscle-liver substrate fluxes in exercising humans and potential effects on hepatic metabolism

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Obesity is associated with earlier pubertal onset in boys

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Evaluation of Serum Insulin-like Factor 3 Quantification by LC-MS/MS as a Biomarker of Leydig Cell Function

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Use of stored serum in the study of time trends and geographical differences in exposure of pregnant women to phthalates

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Increases in bioactive IGF do not parallel increases in total IGF-I during growth hormone treatment of children born SGA

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

CONTEXT: Detailed evaluation of pubertal progression in girls from longitudinal studies is sparse and the phenomenon of transient thelarche (TT), defined as the appearance, regression and subsequent reappearance of breast buds, in healthy girls remains undescribed.

OBJECTIVE: To describe TT in terms of pubertal progression, growth, genotypes and reproductive hormones and to apply new puberty nomograms for breast stages, pubic hair and menarche.

DESIGN: A prospective, longitudinal population-based study.

SETTING: Healthy school children in Denmark.

PATIENTS OR OTHER PARTICIPANTS: 98 healthy, Caucasian girls followed longitudinally as part of COPENHAGEN Puberty Study were included in the evaluation of TT. A total of 1466 girls from two cross-sectional studies were included in the creation of the puberty nomograms.

INTERVENTION(S): None.

MAIN OUTCOME MEASURE(S): Pubertal progression, specifically thelarche, reproductive hormones, genotype, and growth.

RESULTS: 12 of 98 (12%) girls experienced TT. A larger proportion of girls with TT entered puberty by the pubarche pathway (50%) compared to girls with normal progression (15.4%), p = 0.014. Girls with TT progressed through puberty normally when evaluated using puberty nomograms. Reproductive hormones and growth velocity were lower at the first (transient) thelarche than the second (permanent) thelarche.

CONCLUSION: TT is a frequent phenomenon that appears to be a peripheral occurrence independent of central puberty. It does not appear to affect subsequent pubertal progression as evaluated by our new puberty nomograms.

OriginalsprogEngelsk
TidsskriftThe Journal of clinical endocrinology and metabolism
Vol/bind102
Udgave nummer3
Sider (fra-til)1001-1008
ISSN0021-972X
DOI
StatusUdgivet - 2017

ID: 49789643