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Region Hovedstaden - en del af Københavns Universitetshospital
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Pubertal onset in boys and girls is influenced by pubertal timing of both parents

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Evaluation of Serum Insulin-like Factor 3 Quantification by LC-MS/MS as a Biomarker of Leydig Cell Function

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Vis graf over relationer

CONTEXT: Epidemiological evidence on maternal and paternal heritability of the wide normal variation within pubertal timing is sparse.

OBJECTIVE: We aimed to estimate the impact of parental pubertal timing on onset of puberty in boys and girls.

DESIGN: Annual pubertal examinations of healthy children in a longitudinal cohort study. Information on parental timing of puberty (earlier, comparable to or later compared to peers) and menarche-age was retrieved from questionnaires.

PARTICIPANTS: 672 girls 846 boys.

MAIN OUTCOME MEASURES: Age at onset of pubic hair (PH2+), breasts (B2+) and menarche in girls and PH2+, genital stage (G2+) and testis > 3 ml with orchidometer (Tvol3+) in boys.

RESULTS: In boys, pubertal onset was significantly associated with pubertal timing of both parents. PH2+ and Tvol3+ were earlier: -11.8 months (95% CI: -16.8;-6.8) / -8.9(-12.8;-4.9) and -9.5(-13.9;-5.1)/ -7.1(-10.4;-3.7) if the father/mother respectively had early pubertal development compared to late. In girls, menarche was significantly associated with both parents' pubertal timing: -10.5 months (-15.9;-5.1) / -10.1 (-14.3;-6.0) if father/mother had early pubertal development compared to late. For onset of PH2+and B2+ in girls estimates were -7.0 months (-12.6;-1.4) and -4.1(-10.6; +2.4)/ -6.7(-11.0;-2.5) and -6.7(-11.0;-2.0) for fathers/ mothers, respectively. Maternal age of menarche was significantly associated with onset of all pubertal milestones except PH2+ in girls.

CONCLUSIONS: Maternal as well as paternal pubertal timing were strong determinants of age at pubertal onset in both girls and boys. Age at breast and pubic hair development in girls, which has declined most during recent years, seemed to be least dependent on heritability.

OriginalsprogEngelsk
TidsskriftThe Journal of clinical endocrinology and metabolism
Vol/bind101
Udgave nummer7
Sider (fra-til)2667-2674
ISSN0021-972X
DOI
StatusUdgivet - 25 mar. 2016

ID: 46427215