TY - JOUR
T1 - Psychometric evaluation of EQ-5D-5L in OHCA survivors from the TTM2 trial
T2 - a post hoc analysis
AU - Bohm, Mattias
AU - Årestedt, Kristofer
AU - Ullén, Susann
AU - Nielsen, Niklas
AU - Dankiewicz, Josef
AU - Friberg, Hans
AU - Nordström, Erik Blennow
AU - Cariou, Alain
AU - Jakobsen, Janus Christian
AU - Grejs, Anders Morten
AU - Haenggi, Matthias
AU - Hammond, Naomi E
AU - Heimburg, Katarina
AU - Keeble, Thomas R
AU - Leithner, Christoph
AU - Rylander, Christian
AU - Undén, Johan
AU - Wise, Matt P
AU - Cronberg, Tobias
AU - Lilja, Gisela
N1 - © 2025 The Author(s).
PY - 2025/7
Y1 - 2025/7
N2 - AIMS: Our aim was to investigate the psychometric properties of the health assessment instrument EQ-5D-5L in OHCA survivors.METHODS: We included survivors from the Targeted Hypothermia versus Targeted Normothermia after OHCA (TTM2) trial, who completed EQ-5D-5L at 6 months. Confirmatory factor analysis was used to evaluate the hypothesised unidimensional latent structure of EQ level sum score (EQ LSS), summarizing scores across Mobility, Self-care, Usual activities, Pain/discomfort, and Anxiety/depression. Differential item functioning was evaluated for age. We examined internal consistency and precision for the EQ LSS. We evaluated construct validity of EQ LSS, EQ value and EQ VAS, using the modified Rankin Scale and Montreal Cognitive Assessment, representing functional outcome and cognitive function-two common health challenges experienced by OHCA survivors.RESULTS: 783 of 939 (84%) eligible survivors were included. Confirmatory factor analysis showed good model fit and strong factor loadings for all dimensions (0.61-0.90). We observed a significant but negligible effect of age on Mobility (β = 0.29, p < 0.001, ΔR2 = 0.019). Internal consistency was 0.88. The floor effect was 35%. Survivors with more functional dependency and/or cognitive problems reported significantly worse health by EQ LSS, EQ value, and EQ VAS (all, p < 0.001).CONCLUSION: The psychometric properties of EQ LSS support its use to measure health status in OHCA research. The strong association between health and functional dependency indicate robust and comparable construct validity for EQ LSS, EQ value, and EQ VAS in this sample.
AB - AIMS: Our aim was to investigate the psychometric properties of the health assessment instrument EQ-5D-5L in OHCA survivors.METHODS: We included survivors from the Targeted Hypothermia versus Targeted Normothermia after OHCA (TTM2) trial, who completed EQ-5D-5L at 6 months. Confirmatory factor analysis was used to evaluate the hypothesised unidimensional latent structure of EQ level sum score (EQ LSS), summarizing scores across Mobility, Self-care, Usual activities, Pain/discomfort, and Anxiety/depression. Differential item functioning was evaluated for age. We examined internal consistency and precision for the EQ LSS. We evaluated construct validity of EQ LSS, EQ value and EQ VAS, using the modified Rankin Scale and Montreal Cognitive Assessment, representing functional outcome and cognitive function-two common health challenges experienced by OHCA survivors.RESULTS: 783 of 939 (84%) eligible survivors were included. Confirmatory factor analysis showed good model fit and strong factor loadings for all dimensions (0.61-0.90). We observed a significant but negligible effect of age on Mobility (β = 0.29, p < 0.001, ΔR2 = 0.019). Internal consistency was 0.88. The floor effect was 35%. Survivors with more functional dependency and/or cognitive problems reported significantly worse health by EQ LSS, EQ value, and EQ VAS (all, p < 0.001).CONCLUSION: The psychometric properties of EQ LSS support its use to measure health status in OHCA research. The strong association between health and functional dependency indicate robust and comparable construct validity for EQ LSS, EQ value, and EQ VAS in this sample.
KW - Cross-sectional studies
KW - Health status
KW - Heart arrest
KW - Patient reported outcome measures
KW - Psychometrics
KW - Validation study
UR - http://www.scopus.com/inward/record.url?scp=105007469351&partnerID=8YFLogxK
U2 - 10.1016/j.resplu.2025.100994
DO - 10.1016/j.resplu.2025.100994
M3 - Journal article
C2 - 40530409
SN - 2666-5204
VL - 24
JO - Resuscitation plus
JF - Resuscitation plus
M1 - 100994
ER -