Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Serotonin release measured in the human brain: a PET study with [11C]CIMBI-36 and d-amphetamine challenge

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Sex differences in opioid reinforcement under a fentanyl vs. food choice procedure in rats

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Effects of clonidine on MMN and P3a amplitude in schizophrenia patients on stable medication

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. In Memoriam: Arvid Carlsson-Pioneering Researcher and Nobel Laureate

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Evaluation of inferential methods for the net benefit and win ratio statistics

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Glucagon-like peptide-1 receptor regulation of basal dopamine transporter activity is species-dependent

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Different preprocessing strategies lead to different conclusions: A [11C]DASB-PET reproducibility study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Towards selective CNS PET imaging of the 5-HT7 receptor system: Past, present and future

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

The main psychedelic component of magic mushrooms is psilocybin, which shows promise as a treatment for depression and other mental disorders. Psychedelic effects are believed to emerge through stimulation of serotonin 2A receptors (5-HT2ARs) by psilocybin's active metabolite, psilocin. We here report for the first time the relationship between intensity of psychedelic effects, cerebral 5-HT2AR occupancy and plasma levels of psilocin in humans. Eight healthy volunteers underwent positron emission tomography (PET) scans with the 5-HT2AR agonist radioligand [11C]Cimbi-36: one at baseline and one or two additional scans on the same day after a single oral intake of psilocybin (3-30 mg). 5-HT2AR occupancy was calculated as the percent change in cerebral 5-HT2AR binding relative to baseline. Subjective psychedelic intensity and plasma psilocin levels were measured during the scans. Relations between subjective intensity, 5-HT2AR occupancy, and plasma psilocin levels were modeled using non-linear regression. Psilocybin intake resulted in dose-related 5-HT2AR occupancies up to 72%; plasma psilocin levels and 5-HT2AR occupancy conformed to a single-site binding model. Subjective intensity was correlated with both 5-HT2AR occupancy and psilocin levels as well as questionnaire scores. We report for the first time that intake of psilocybin leads to significant 5-HT2AR occupancy in the human brain, and that both psilocin plasma levels and 5-HT2AR occupancy are closely associated with subjective intensity ratings, strongly supporting that stimulation of 5-HT2AR is a key determinant for the psychedelic experience. Important for clinical studies, psilocin time-concentration curves varied but psilocin levels were closely associated with psychedelic experience.

OriginalsprogEngelsk
TidsskriftNeuropsychopharmacology
Vol/bind44
Udgave nummer7
Sider (fra-til)1328-1334
Antal sider7
ISSN0893-133X
DOI
StatusUdgivet - jun. 2019

ID: 56708623