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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Pseudomonas aeruginosa Biofilms: Mechanisms of Immune Evasion

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Antigenic Variation and the Genetics and Epigenetics of the PfEMP1 Erythrocyte Surface Antigens in Plasmodium falciparum Malaria

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The efficacy of topical agents used in wounds for managing chronic biofilm infections: A systematic review

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The environmental occurrence of Pseudomonas aeruginosa

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Biofilms of Mycobacterium abscessus complex can be sensitized to antibiotics by disaggregation and oxygenation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Minimum information guideline for spectrofotometric and fluorometric methods to assess biofilm formation in microplates

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  5. Is pseudarthrosis after spinal instrumentation caused by a chronic infection?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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The opportunistic gram-negative bacterium Pseudomonas aeruginosa is implicated in many chronic infections and is readily isolated from chronic wounds, medical devices, and the lungs of cystic fibrosis patients. P. aeruginosa is believed to persist in the host organism due to its capacity to form biofilms, which protect the aggregated, biopolymer-embedded bacteria from the detrimental actions of antibiotic treatments and host immunity. A key component in the protection against innate immunity is rhamnolipid, which is a quorum sensing (QS)-regulated virulence factor. QS is a cell-to-cell signaling mechanism used to coordinate expression of virulence and protection of aggregated biofilm cells. Rhamnolipids are known for their ability to cause hemolysis and have been shown to cause lysis of several cellular components of the human immune system, for example, macrophages and polymorphonuclear leukocytes (PMNs). In this chapter, the interplay between P. aeruginosa and the PMNs in chronic infections is discussed with focus on the role of rhamnolipids and extracellular DNA.
OriginalsprogEngelsk
TidsskriftAdvances in Applied Microbiology
Vol/bind86
Sider (fra-til)1-40
Antal sider40
ISSN0065-2164
DOI
StatusUdgivet - 2014

ID: 42497217