Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth

N Høiby; H Krogh Johansen; C Moser; Z Song; O Ciofu; A Kharazmi

doi:10.1016/s1286-4579(00)01349-6

Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth

N Høiby, H Krogh Johansen, C Moser, Z Song, O Ciofu, A Kharazmi

310 Citationer (Scopus)

Abstract

The biofilm mode of growth is the survival strategy of environmental bacteria like Pseudomonas aeruginosa. Such P. aeruginosa biofilms also occur in the lungs of chronically infected cystic fibrosis patients, where they protect the bacteria against antibiotics and the immune response. The lung tissue damage is due to immune complex mediated chronic inflammation dominated by polymorphonuclear leukocytes releasing proteases and oxygen radicals.

Originalsprog	Engelsk
Tidsskrift	Microbes and Infection
Vol/bind	3
Udgave nummer	1
Sider (fra-til)	23-35
Antal sider	13
ISSN	1286-4579
DOI	https://doi.org/10.1016/s1286-4579(00)01349-6
Status	Udgivet - jan. 2001
Udgivet eksternt	Ja

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10.1016/s1286-4579(00)01349-6

Citationsformater

@article{d20befb7b56d4b488d5169f1df74d36a,

title = "Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth",

abstract = "The biofilm mode of growth is the survival strategy of environmental bacteria like Pseudomonas aeruginosa. Such P. aeruginosa biofilms also occur in the lungs of chronically infected cystic fibrosis patients, where they protect the bacteria against antibiotics and the immune response. The lung tissue damage is due to immune complex mediated chronic inflammation dominated by polymorphonuclear leukocytes releasing proteases and oxygen radicals.",

keywords = "Animals, Anti-Bacterial Agents/pharmacology, Biofilms, Chronic Disease, Cystic Fibrosis/immunology, Drug Resistance, Microbial, Endopeptidases/metabolism, Humans, Inflammation/immunology, Lung/microbiology, Neutrophils/metabolism, Pseudomonas Infections/microbiology, Pseudomonas aeruginosa/drug effects",

author = "N H{\o}iby and {Krogh Johansen}, H and C Moser and Z Song and O Ciofu and A Kharazmi",

year = "2001",

month = jan,

doi = "10.1016/s1286-4579(00)01349-6",

language = "English",

volume = "3",

pages = "23--35",

journal = "Microbes and Infection",

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TY - JOUR

T1 - Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth

AU - Høiby, N

AU - Krogh Johansen, H

AU - Moser, C

AU - Song, Z

AU - Ciofu, O

AU - Kharazmi, A

PY - 2001/1

Y1 - 2001/1

N2 - The biofilm mode of growth is the survival strategy of environmental bacteria like Pseudomonas aeruginosa. Such P. aeruginosa biofilms also occur in the lungs of chronically infected cystic fibrosis patients, where they protect the bacteria against antibiotics and the immune response. The lung tissue damage is due to immune complex mediated chronic inflammation dominated by polymorphonuclear leukocytes releasing proteases and oxygen radicals.

AB - The biofilm mode of growth is the survival strategy of environmental bacteria like Pseudomonas aeruginosa. Such P. aeruginosa biofilms also occur in the lungs of chronically infected cystic fibrosis patients, where they protect the bacteria against antibiotics and the immune response. The lung tissue damage is due to immune complex mediated chronic inflammation dominated by polymorphonuclear leukocytes releasing proteases and oxygen radicals.

KW - Animals

KW - Anti-Bacterial Agents/pharmacology

KW - Biofilms

KW - Chronic Disease

KW - Cystic Fibrosis/immunology

KW - Drug Resistance, Microbial

KW - Endopeptidases/metabolism

KW - Humans

KW - Inflammation/immunology

KW - Lung/microbiology

KW - Neutrophils/metabolism

KW - Pseudomonas Infections/microbiology

KW - Pseudomonas aeruginosa/drug effects

U2 - 10.1016/s1286-4579(00)01349-6

DO - 10.1016/s1286-4579(00)01349-6

M3 - Review

C2 - 11226851

SN - 1286-4579

VL - 3

SP - 23

EP - 35

JO - Microbes and Infection

JF - Microbes and Infection

IS - 1

ER -

Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth

Abstract

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