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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Protoparvovirus Cell Entry

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

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Vis graf over relationer

The Protoparvovirus (PtPV) genus of the Parvoviridae family of viruses includes important animal pathogens and reference molecular models for the entire family. Some virus members of the PtPV genus have arisen as promising tools to treat tumoral processes, as they exhibit marked oncotropism and oncolytic activities while being nonpathogenic for humans. The PtPVs invade and replicate within the nucleus making extensive use of the transport, transcription and replication machineries of the host cells. In order to reach the nucleus, PtPVs need to cross over several intracellular barriers and traffic through different cell compartments, which limit their infection efficiency. In this review we summarize molecular interactions, capsid structural transitions and hijacking of cellular processes, by which the PtPVs enter and deliver their single-stranded DNA genome into the host cell nucleus. Understanding mechanisms that govern the complex PtPV entry will be instrumental in developing approaches to boost their anticancer therapeutic potential and improving their safety profile.

OriginalsprogEngelsk
TidsskriftViruses
Vol/bind9
Udgave nummer11
ISSN1999-4915
DOI
StatusUdgivet - 26 okt. 2017

ID: 51951580