Proteoglycan Remodeling Is Accelerated in Females with Angina Pectoris and Diffuse Myocardial Fibrosis: the iPOWER Study

Naja Dam Mygind, Signe Holm Nielsen, Marie Mide Michelsen, Adam Pena, Daria Frestad Bechsgaard, Elena Suhrs, Kira Bang Bove, Federica Genovese, Henning Bay Nielsen, Morten Karsdal, Niels Vejlstrup, Eva Prescott, Jens Kastrup

Abstract

Angina and no obstructive coronary artery disease (CAD) have an unfavorable prognosis, possibly due to diffuse myocardial fibrosis (DMF). In DMF the proteoglycans biglycan and versican are actively remodeled by matrix metalloproteinase. We investigated biglycan and versican in females with angina and possible DMF assessed by cardiac magnetic resonance (CMR). Seventy-one females with angina and no obstructive CAD were included. Asymptomatic females served as controls. Versican and biglycan were measured and CMR was performed measuring extracellular volume. Biglycan and versican levels were higher in symptomatic females compared with controls; 31.4 ng/mL vs. 16.4 ng/mL (p < 0.001) and 2.1 ng/mL vs. 1.8 ng/mL (p < 0.001) and moderately correlated to extracellular volume (r 2 = 0.38, p<0.001 and r 2 = 0.26, p = 0.015). Turnover of biglycan and versican was increased in angina females compared with controls and associated with extracellular volume, supporting a link between angina with no obstructive CAD and fibrotic remodeling. Graphical abstract: [Figure not available: see fulltext.]

OriginalsprogEngelsk
TidsskriftJournal of Cardiovascular Translational Research
Vol/bind14
Udgave nummer5
Sider (fra-til)921-929
Antal sider9
ISSN1937-5387
DOI
StatusUdgivet - okt. 2021

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