TY - JOUR
T1 - Proteoglycan Remodeling Is Accelerated in Females with Angina Pectoris and Diffuse Myocardial Fibrosis
T2 - the iPOWER Study
AU - Mygind, Naja Dam
AU - Nielsen, Signe Holm
AU - Michelsen, Marie Mide
AU - Pena, Adam
AU - Bechsgaard, Daria Frestad
AU - Suhrs, Elena
AU - Bove, Kira Bang
AU - Genovese, Federica
AU - Nielsen, Henning Bay
AU - Karsdal, Morten
AU - Vejlstrup, Niels
AU - Prescott, Eva
AU - Kastrup, Jens
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/10
Y1 - 2021/10
N2 - Angina and no obstructive coronary artery disease (CAD) have an unfavorable prognosis, possibly due to diffuse myocardial fibrosis (DMF). In DMF the proteoglycans biglycan and versican are actively remodeled by matrix metalloproteinase. We investigated biglycan and versican in females with angina and possible DMF assessed by cardiac magnetic resonance (CMR). Seventy-one females with angina and no obstructive CAD were included. Asymptomatic females served as controls. Versican and biglycan were measured and CMR was performed measuring extracellular volume. Biglycan and versican levels were higher in symptomatic females compared with controls; 31.4 ng/mL vs. 16.4 ng/mL (p < 0.001) and 2.1 ng/mL vs. 1.8 ng/mL (p < 0.001) and moderately correlated to extracellular volume (r
2 = 0.38, p<0.001 and r
2 = 0.26, p = 0.015). Turnover of biglycan and versican was increased in angina females compared with controls and associated with extracellular volume, supporting a link between angina with no obstructive CAD and fibrotic remodeling. Graphical abstract: [Figure not available: see fulltext.]
AB - Angina and no obstructive coronary artery disease (CAD) have an unfavorable prognosis, possibly due to diffuse myocardial fibrosis (DMF). In DMF the proteoglycans biglycan and versican are actively remodeled by matrix metalloproteinase. We investigated biglycan and versican in females with angina and possible DMF assessed by cardiac magnetic resonance (CMR). Seventy-one females with angina and no obstructive CAD were included. Asymptomatic females served as controls. Versican and biglycan were measured and CMR was performed measuring extracellular volume. Biglycan and versican levels were higher in symptomatic females compared with controls; 31.4 ng/mL vs. 16.4 ng/mL (p < 0.001) and 2.1 ng/mL vs. 1.8 ng/mL (p < 0.001) and moderately correlated to extracellular volume (r
2 = 0.38, p<0.001 and r
2 = 0.26, p = 0.015). Turnover of biglycan and versican was increased in angina females compared with controls and associated with extracellular volume, supporting a link between angina with no obstructive CAD and fibrotic remodeling. Graphical abstract: [Figure not available: see fulltext.]
KW - Angina pectoris
KW - Cardiac magnetic resonance
KW - Coronary microvascular disease
KW - Diffuse myocardial fibrosis
KW - Extracellular matrix
KW - Proteoglycan
KW - T1 mapping
UR - http://www.scopus.com/inward/record.url?scp=85101813100&partnerID=8YFLogxK
U2 - 10.1007/s12265-021-10106-y
DO - 10.1007/s12265-021-10106-y
M3 - Journal article
C2 - 33649986
VL - 14
SP - 921
EP - 929
JO - Journal of Cardiovascular Translational Research
JF - Journal of Cardiovascular Translational Research
SN - 1937-5387
IS - 5
ER -