Protein profiling of cerebrospinal fluid

Anja H Simonsen

doi:10.1007/978-1-61779-418-6_8

Protein profiling of cerebrospinal fluid

Anja H Simonsen

Afdeling for Hjerne- og Nervesygdomme

3 Citationer (Scopus)

Abstract

The cerebrospinal fluid (CSF) perfuses the brain and spinal cord. CSF contains proteins and peptides important for brain physiology and potentially also relevant for brain pathology. Hence, CSF is the perfect source to search for new biomarkers to improve diagnosis of neurological diseases as well as to monitor the performance of disease-modifying drugs. This chapter presents methods for SELDI-TOF profiling of CSF as well as useful advice regarding pre-analytical factors to be considered.

Originalsprog	Engelsk
Tidsskrift	Methods in Molecular Biology
Vol/bind	818
Sider (fra-til)	109-17
Antal sider	9
ISSN	1064-3745
DOI	https://doi.org/10.1007/978-1-61779-418-6_8
Status	Udgivet - 2012

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10.1007/978-1-61779-418-6_8

Citationsformater

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title = "Protein profiling of cerebrospinal fluid",

abstract = "The cerebrospinal fluid (CSF) perfuses the brain and spinal cord. CSF contains proteins and peptides important for brain physiology and potentially also relevant for brain pathology. Hence, CSF is the perfect source to search for new biomarkers to improve diagnosis of neurological diseases as well as to monitor the performance of disease-modifying drugs. This chapter presents methods for SELDI-TOF profiling of CSF as well as useful advice regarding pre-analytical factors to be considered.",

keywords = "Analytic Sample Preparation Methods, Cerebrospinal Fluid Proteins, Protein Array Analysis, Reference Standards, Specimen Handling, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization",

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AU - Simonsen, Anja H

PY - 2012

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N2 - The cerebrospinal fluid (CSF) perfuses the brain and spinal cord. CSF contains proteins and peptides important for brain physiology and potentially also relevant for brain pathology. Hence, CSF is the perfect source to search for new biomarkers to improve diagnosis of neurological diseases as well as to monitor the performance of disease-modifying drugs. This chapter presents methods for SELDI-TOF profiling of CSF as well as useful advice regarding pre-analytical factors to be considered.

AB - The cerebrospinal fluid (CSF) perfuses the brain and spinal cord. CSF contains proteins and peptides important for brain physiology and potentially also relevant for brain pathology. Hence, CSF is the perfect source to search for new biomarkers to improve diagnosis of neurological diseases as well as to monitor the performance of disease-modifying drugs. This chapter presents methods for SELDI-TOF profiling of CSF as well as useful advice regarding pre-analytical factors to be considered.

KW - Analytic Sample Preparation Methods

KW - Cerebrospinal Fluid Proteins

KW - Protein Array Analysis

KW - Reference Standards

KW - Specimen Handling

KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

U2 - 10.1007/978-1-61779-418-6_8

DO - 10.1007/978-1-61779-418-6_8

M3 - Journal article

C2 - 22083819

SN - 1064-3745

VL - 818

SP - 109

EP - 117

JO - Methods in Molecular Biology

JF - Methods in Molecular Biology

ER -

Protein profiling of cerebrospinal fluid

Abstract

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