Protein changes in the retina following experimental retinal detachment in rabbits

Nakul Mandal; Geoffrey P Lewis; Steven K Fisher; Steffen Heegaard; Jan U Prause; Morten la Cour; Henrik Vorum; Bent Honore

Protein changes in the retina following experimental retinal detachment in rabbits

Nakul Mandal, Geoffrey P Lewis, Steven K Fisher, Steffen Heegaard, Jan U Prause, Morten la Cour, Henrik Vorum, Bent Honore

Afdeling for Øjensygdomme

20 Citationer (Scopus)

Abstract

Retinal detachment leads to the widespread cellular remodeling of the retina. The purpose of this study was to identify protein changes that accompany these cellular alterations by comparing the proteomic profiles of sham and experimentally detached rabbit retina. Elucidation of the proteins most dramatically affected by retinal detachment would add further understanding to the pathophysiology of this condition, and potentially identify therapeutic targets useful in preventing the deleterious effects of detachment, including photoreceptor cell death and the activation of non-neuronal microglial and Müller cells.

Originalsprog	Engelsk
Tidsskrift	Molecular Vision
Vol/bind	17
Sider (fra-til)	2634-48
Antal sider	15
ISSN	1090-0535
Status	Udgivet - 2011

Citationsformater

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title = "Protein changes in the retina following experimental retinal detachment in rabbits",

abstract = "Retinal detachment leads to the widespread cellular remodeling of the retina. The purpose of this study was to identify protein changes that accompany these cellular alterations by comparing the proteomic profiles of sham and experimentally detached rabbit retina. Elucidation of the proteins most dramatically affected by retinal detachment would add further understanding to the pathophysiology of this condition, and potentially identify therapeutic targets useful in preventing the deleterious effects of detachment, including photoreceptor cell death and the activation of non-neuronal microglial and M{\"u}ller cells.",

author = "Nakul Mandal and Lewis, {Geoffrey P} and Fisher, {Steven K} and Steffen Heegaard and Prause, {Jan U} and {la Cour}, Morten and Henrik Vorum and Bent Honore",

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T1 - Protein changes in the retina following experimental retinal detachment in rabbits

AU - Mandal, Nakul

AU - Lewis, Geoffrey P

AU - Fisher, Steven K

AU - Heegaard, Steffen

AU - Prause, Jan U

AU - la Cour, Morten

AU - Vorum, Henrik

AU - Honore, Bent

PY - 2011

Y1 - 2011

N2 - Retinal detachment leads to the widespread cellular remodeling of the retina. The purpose of this study was to identify protein changes that accompany these cellular alterations by comparing the proteomic profiles of sham and experimentally detached rabbit retina. Elucidation of the proteins most dramatically affected by retinal detachment would add further understanding to the pathophysiology of this condition, and potentially identify therapeutic targets useful in preventing the deleterious effects of detachment, including photoreceptor cell death and the activation of non-neuronal microglial and Müller cells.

AB - Retinal detachment leads to the widespread cellular remodeling of the retina. The purpose of this study was to identify protein changes that accompany these cellular alterations by comparing the proteomic profiles of sham and experimentally detached rabbit retina. Elucidation of the proteins most dramatically affected by retinal detachment would add further understanding to the pathophysiology of this condition, and potentially identify therapeutic targets useful in preventing the deleterious effects of detachment, including photoreceptor cell death and the activation of non-neuronal microglial and Müller cells.

M3 - Journal article

C2 - 22065916

SN - 1090-0535

VL - 17

SP - 2634

EP - 2648

JO - Molecular Vision

JF - Molecular Vision

ER -

Protein changes in the retina following experimental retinal detachment in rabbits

Abstract

Fingeraftryk

Citationsformater