Prostate specific membrane antigen- a target for imaging and therapy with radionuclides

Kirsten Bouchelouche, Peter L Choyke, Jacek Capala

113 Citationer (Scopus)

Abstract

Prostate cancer continues to represent a major health problem, and yet there is no effective treatment available for advanced metastatic disease. Thus, there is an urgent need for the development of more effective treatment modalities that could improve the outcome. Because prostate specific membrane antigen (PSMA), a transmembrane protein, is expressed by virtually all prostate cancers, and its expression is further increased in poorly differentiated, metastatic, and hormone-refractory carcinomas, it is a very attractive target. Molecules targeting PSMA can be labelled with radionuclides to become both diagnostic and/or therapeutic agents. The use of PSMA binding agents, labelled with diagnostic and therapeutic radio-isotopes, opens up the potential for a new era of personalized management of metastatic prostate cancer.
OriginalsprogEngelsk
TidsskriftDiscovery medicine
Vol/bind9
Udgave nummer44
Sider (fra-til)55-61
Antal sider7
ISSN1539-6509
StatusUdgivet - 1 jan. 2010

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