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Prostate Artery Embolization for Lower Urinary Tract Symptoms in Men Unfit for Surgery

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@article{f053d8af149b496297b366ed128dbaa6,
title = "Prostate Artery Embolization for Lower Urinary Tract Symptoms in Men Unfit for Surgery",
abstract = "Nearly one in three men develop lower urinary tract symptoms (LUTS) and 10{\%} clinically progress despite medication. Transurethral resection of the prostate (TURP) is the reference standard for symptoms refractory to medical treatment. However, some patients cannot tolerate TURP for medical (e.g., comorbidity) or technical (e.g., large prostate) reasons. This study estimated the safety and effect of prostate artery embolization (PAE) in men unfit for surgery. A prospective, single-centre trial including men with LUTS or urinary retention secondary to benign prostatic hyperplasia (BPH) who were unfit for surgery. The primary objective was to treat urinary retention and LUTS. Outcome measures included International Prostate Symptom Score (IPSS), quality of life (IPSS-QoL), International Index of Erectile Function (IIEF-5), prostate volume (PV), prostate-specific antigen (PSA), peak void flow (Qmax), post-void residual (PVR), and complications. A p-value < 0.05 was considered statistically significant. Eleven consecutive patients with a mean age of 75.2 (SD ± 8.2) underwent PAE. Catheter removal was successful in 60{\%}. IPSS-QoL improved 4.5 points (95{\%} CI: -5.6; -3.4), and PV was reduced by 26.2 cm3 (95{\%} CI: -50.9; -2.3). None of the remaining outcomes changed. No major complications occurred. PAE was effective and safe for LUTS and urinary retention associated with BPH in men unfit for surgery.",
author = "Brian Malling and Lars L{\"o}nn and Jensen, {Ruben Juhl} and Mats Lindh and Susanne Frevert and Klaus Brasso and R{\o}der, {Martin Andreas}",
year = "2019",
month = "4",
day = "25",
doi = "10.3390/diagnostics9020046",
language = "English",
volume = "9",
journal = "Diagnostics",
issn = "2075-4418",
publisher = "M D P I AG",
number = "2",

}

RIS

TY - JOUR

T1 - Prostate Artery Embolization for Lower Urinary Tract Symptoms in Men Unfit for Surgery

AU - Malling, Brian

AU - Lönn, Lars

AU - Jensen, Ruben Juhl

AU - Lindh, Mats

AU - Frevert, Susanne

AU - Brasso, Klaus

AU - Røder, Martin Andreas

PY - 2019/4/25

Y1 - 2019/4/25

N2 - Nearly one in three men develop lower urinary tract symptoms (LUTS) and 10% clinically progress despite medication. Transurethral resection of the prostate (TURP) is the reference standard for symptoms refractory to medical treatment. However, some patients cannot tolerate TURP for medical (e.g., comorbidity) or technical (e.g., large prostate) reasons. This study estimated the safety and effect of prostate artery embolization (PAE) in men unfit for surgery. A prospective, single-centre trial including men with LUTS or urinary retention secondary to benign prostatic hyperplasia (BPH) who were unfit for surgery. The primary objective was to treat urinary retention and LUTS. Outcome measures included International Prostate Symptom Score (IPSS), quality of life (IPSS-QoL), International Index of Erectile Function (IIEF-5), prostate volume (PV), prostate-specific antigen (PSA), peak void flow (Qmax), post-void residual (PVR), and complications. A p-value < 0.05 was considered statistically significant. Eleven consecutive patients with a mean age of 75.2 (SD ± 8.2) underwent PAE. Catheter removal was successful in 60%. IPSS-QoL improved 4.5 points (95% CI: -5.6; -3.4), and PV was reduced by 26.2 cm3 (95% CI: -50.9; -2.3). None of the remaining outcomes changed. No major complications occurred. PAE was effective and safe for LUTS and urinary retention associated with BPH in men unfit for surgery.

AB - Nearly one in three men develop lower urinary tract symptoms (LUTS) and 10% clinically progress despite medication. Transurethral resection of the prostate (TURP) is the reference standard for symptoms refractory to medical treatment. However, some patients cannot tolerate TURP for medical (e.g., comorbidity) or technical (e.g., large prostate) reasons. This study estimated the safety and effect of prostate artery embolization (PAE) in men unfit for surgery. A prospective, single-centre trial including men with LUTS or urinary retention secondary to benign prostatic hyperplasia (BPH) who were unfit for surgery. The primary objective was to treat urinary retention and LUTS. Outcome measures included International Prostate Symptom Score (IPSS), quality of life (IPSS-QoL), International Index of Erectile Function (IIEF-5), prostate volume (PV), prostate-specific antigen (PSA), peak void flow (Qmax), post-void residual (PVR), and complications. A p-value < 0.05 was considered statistically significant. Eleven consecutive patients with a mean age of 75.2 (SD ± 8.2) underwent PAE. Catheter removal was successful in 60%. IPSS-QoL improved 4.5 points (95% CI: -5.6; -3.4), and PV was reduced by 26.2 cm3 (95% CI: -50.9; -2.3). None of the remaining outcomes changed. No major complications occurred. PAE was effective and safe for LUTS and urinary retention associated with BPH in men unfit for surgery.

U2 - 10.3390/diagnostics9020046

DO - 10.3390/diagnostics9020046

M3 - Journal article

VL - 9

JO - Diagnostics

JF - Diagnostics

SN - 2075-4418

IS - 2

ER -

ID: 57104007