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Prostate artery embolisation for benign prostatic hyperplasia: a systematic review and meta-analysis

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

  1. Active Surveillance Versus Radical Prostatectomy in Favorable-risk Localized Prostate Cancer

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  2. Risk of cardiovascular events in men treated for prostate cancer compared with prostate cancer-free men

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  3. Prostate Artery Embolization for Lower Urinary Tract Symptoms in Men Unfit for Surgery

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  4. 5hmC Level Predicts Biochemical Failure Following Radical Prostatectomy in Prostate Cancer Patients with ERG Negative Tumors

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Objectives: Prostate artery embolisation (PAE) is a new minimally invasive treatment for lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH). The purpose of this study was to review the efficacy and safety of PAE in the treatment of BPH with LUTS. Methods: A systematic review performed according to the PRISMA guidelines with a pre-specified search strategy for PubMed, Web of Science, Cochrane Library and Embase databases protocol (PROSPERO ID: CRD42017059196). Trials studying the efficacy of prostate artery embolisation to treat LUTS with more than ten participants and follow-up longer than 6 months were included by two independent authors. Outcomes investigated were International Prostate Symptom Score (IPSS), quality of life (QoL), International Index of Erectile Function (IIEF-5), prostate volume (PV), prostate-specific antigen (PSA), peak void flow (Qmax), post-void residual (PVR) and complications. To summarise mean change from baseline, a meta-analysis was done using the random-effects model. Results: The search returned 210 references, of which 13 studies met the inclusion criteria, representing 1,254 patients. Patients in the included studies with data available for meta-analysis had moderate to severe LUTS and a mean IPSS of 23.5. Statistically significant (p value < 0.05) improvements of all investigated outcomes were seen at 12-month follow-up. Major complications were reported in 0.3% of the cases. Conclusions: Our findings suggest that PAE can reduce moderate to severe LUTS in men with BPH with a low risk of complications. Key Points: • Prostate artery embolisation (PAE) improved International Prostate Symptom Score (IPSS) by 67%. • Major complications after PAE are very rare. • Use of cone-beam CT may reduce risk of non-target embolisation.

OriginalsprogEngelsk
TidsskriftEuropean Radiology
Vol/bind29
Udgave nummer1
Sider (fra-til)287-98
Antal sider12
ISSN0938-7994
DOI
StatusUdgivet - 1 jan. 2019

ID: 55695573