Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Prospective studies exploring the possible impact of an ID3 polymorphism on changes in obesity measures

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{1f428728573840ec9d46f4887e482039,
title = "Prospective studies exploring the possible impact of an ID3 polymorphism on changes in obesity measures",
abstract = "OBJECTIVE: Changes in fat mass depend on adipogenesis and angiogenesis, mechanisms regulated by the inhibitor of differentiation-3 (ID3). Id3 knockout mice showed attenuated increases in BMI and visceral fat mass. We hypothesized that the ID3 missense variant (rs11574-A) would lead to an attenuated increase over time in fat mass, BMI, waist circumference (WC), and waist-hip ratio (WHR) in humans.METHODS: The genotyped study populations included the Obesity Research Group - Genetics (ORGGEN) cohort, a cohort of men with obesity (N = 716) and of randomly selected men (N = 826) from the Danish draft register who were examined at mean ages of 20 and 46 years, and the Inter99 (N = 6,116) and Health2006 (N = 2,761) cohorts, two population-based samples of middle-aged people, followed up after 5 years.RESULTS: In meta-analyses of all data, no association was found between rs11574-A and changes in BMI, WC, WHR, or fat mass. We found an association between rs11574-A and cross-sectional BMI (N = 10,359, β: -0.16 kg/m2per allele, 95{\%} CI: -0.30 to -0.01, P = 0.033) and fat mass (N = 4,188, β: -0.52 kg/m2per allele, 95{\%} CI: -1.03 to -0.01, P = 0.046).CONCLUSIONS: No consistent impact of the genetic variant on changes in fat mass, BMI, or fat distribution was found in three Danish cohorts.",
keywords = "Journal Article",
author = "Mathilde Svendstrup and Appel, {Emil V R} and Sandholt, {Camilla H} and Ahluwalia, {Tarunveer S} and {\"A}ngquist, {Lars H} and Thuesen, {Betina H} and J{\o}rgensen, {Marit E} and Oluf Pedersen and Niels Grarup and Torben Hansen and S{\o}rensen, {Thorkild I A} and Henrik Vestergaard",
note = "{\circledC} 2018 The Obesity Society.",
year = "2018",
month = "4",
doi = "10.1002/oby.22109",
language = "English",
volume = "26",
pages = "747--754",
journal = "Obesity",
issn = "1930-7381",
publisher = "Nature Publishing Group",
number = "4",

}

RIS

TY - JOUR

T1 - Prospective studies exploring the possible impact of an ID3 polymorphism on changes in obesity measures

AU - Svendstrup, Mathilde

AU - Appel, Emil V R

AU - Sandholt, Camilla H

AU - Ahluwalia, Tarunveer S

AU - Ängquist, Lars H

AU - Thuesen, Betina H

AU - Jørgensen, Marit E

AU - Pedersen, Oluf

AU - Grarup, Niels

AU - Hansen, Torben

AU - Sørensen, Thorkild I A

AU - Vestergaard, Henrik

N1 - © 2018 The Obesity Society.

PY - 2018/4

Y1 - 2018/4

N2 - OBJECTIVE: Changes in fat mass depend on adipogenesis and angiogenesis, mechanisms regulated by the inhibitor of differentiation-3 (ID3). Id3 knockout mice showed attenuated increases in BMI and visceral fat mass. We hypothesized that the ID3 missense variant (rs11574-A) would lead to an attenuated increase over time in fat mass, BMI, waist circumference (WC), and waist-hip ratio (WHR) in humans.METHODS: The genotyped study populations included the Obesity Research Group - Genetics (ORGGEN) cohort, a cohort of men with obesity (N = 716) and of randomly selected men (N = 826) from the Danish draft register who were examined at mean ages of 20 and 46 years, and the Inter99 (N = 6,116) and Health2006 (N = 2,761) cohorts, two population-based samples of middle-aged people, followed up after 5 years.RESULTS: In meta-analyses of all data, no association was found between rs11574-A and changes in BMI, WC, WHR, or fat mass. We found an association between rs11574-A and cross-sectional BMI (N = 10,359, β: -0.16 kg/m2per allele, 95% CI: -0.30 to -0.01, P = 0.033) and fat mass (N = 4,188, β: -0.52 kg/m2per allele, 95% CI: -1.03 to -0.01, P = 0.046).CONCLUSIONS: No consistent impact of the genetic variant on changes in fat mass, BMI, or fat distribution was found in three Danish cohorts.

AB - OBJECTIVE: Changes in fat mass depend on adipogenesis and angiogenesis, mechanisms regulated by the inhibitor of differentiation-3 (ID3). Id3 knockout mice showed attenuated increases in BMI and visceral fat mass. We hypothesized that the ID3 missense variant (rs11574-A) would lead to an attenuated increase over time in fat mass, BMI, waist circumference (WC), and waist-hip ratio (WHR) in humans.METHODS: The genotyped study populations included the Obesity Research Group - Genetics (ORGGEN) cohort, a cohort of men with obesity (N = 716) and of randomly selected men (N = 826) from the Danish draft register who were examined at mean ages of 20 and 46 years, and the Inter99 (N = 6,116) and Health2006 (N = 2,761) cohorts, two population-based samples of middle-aged people, followed up after 5 years.RESULTS: In meta-analyses of all data, no association was found between rs11574-A and changes in BMI, WC, WHR, or fat mass. We found an association between rs11574-A and cross-sectional BMI (N = 10,359, β: -0.16 kg/m2per allele, 95% CI: -0.30 to -0.01, P = 0.033) and fat mass (N = 4,188, β: -0.52 kg/m2per allele, 95% CI: -1.03 to -0.01, P = 0.046).CONCLUSIONS: No consistent impact of the genetic variant on changes in fat mass, BMI, or fat distribution was found in three Danish cohorts.

KW - Journal Article

U2 - 10.1002/oby.22109

DO - 10.1002/oby.22109

M3 - Journal article

VL - 26

SP - 747

EP - 754

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 4

ER -

ID: 52758576