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Proposed update to the taxonomy of the genera Hepacivirus and Pegivirus within the Flaviviridae family

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DOI

  1. Ribavirin-induced mutagenesis across the complete open reading frame of hepatitis C virus genotypes 1a and 3a

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Proposed revision to the taxonomy of the genus Pestivirus, family Flaviviridae

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. ICTV Virus Taxonomy Profile: Flaviviridae

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Ribavirin inhibition of cell-culture infectious hepatitis C genotype 1-3 viruses is strain-dependent

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Genome Sequence of an Unknown Subtype of Hepatitis C Virus Genotype 6: Another Piece for the Taxonomic Puzzle

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Virus Adaptation and Selection Following Challenge of Animals Vaccinated against Classical Swine Fever Virus

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Replicons of a rodent hepatitis C model virus permit selection of highly permissive cells

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Donald B Smith
  • Paul Becher
  • Jens Bukh
  • Ernest A Gould
  • Gregor Meyers
  • Thomas Monath
  • A Scott Muerhoff
  • Alexander Pletnev
  • Rebecca Rico-Hesse
  • Jack T Stapleton
  • Peter Simmonds
Vis graf over relationer

Proposals are described for the assignment of recently reported viruses, infecting rodents, bats and other mammalian species, to new species within the Hepacivirus and Pegivirus genera (Family Flaviviridae). Assignments into 14 Hepacivirus species (Hepacivirus A to N) and 11 Pegivirus species (Pegivirus A to K) are based on phylogenetic relationships and sequence distances between conserved regions extracted from complete coding sequences of each proposed taxon. We propose that the species hepatitis C virus is renamed Hepacivirus C in order to acknowledge its unique historical position and so as to minimise confusion. Despite the newly documented genetic diversity of hepaciviruses and pegiviruses, members of these genera remain phylogenetically distinct, and differ in hepatotropism and the possession of a basic core protein; pegiviruses in general lack these features. However, other characteristics that were originally used to support their division into separate genera are no longer definitive; there is overlap between the two genera in the type of internal ribosomal entry site (IRES) and the presence of miR-122 sites in the 5'untranslated region (UTR), the predicted number of N-linked glycosylation sites in the envelope E1 and E2 proteins, the presence of poly U tracts in the 3' UTR and the propensity of viruses to establish a persistent infection. While all classified hepaciviruses and pegiviruses have mammalian hosts, the recent description of a hepaci-/pegi-like virus from a shark and the likely existence of further homologues in other non-mammalian species indicates that further species or genera remain to be defined in the future.

OriginalsprogEngelsk
TidsskriftThe Journal of general virology
Vol/bind97
Udgave nummer11
Sider (fra-til)2894-29070
ISSN0022-1317
DOI
StatusUdgivet - nov. 2016

ID: 49102289