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Proposed Key Characteristics of Male Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Evidence in Human Health Hazard Assessments

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Arzuaga, X, Smith, MT, Gibbons, CF, Skakkebæk, NE, Yost, EE, Beverly, BEJ, Hotchkiss, AK, Hauser, R, Pagani, RL, Schrader, SM, Zeise, L & Prins, GS 2019, 'Proposed Key Characteristics of Male Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Evidence in Human Health Hazard Assessments' Environmental Health Perspectives, bind 127, nr. 6, s. 65001. https://doi.org/10.1289/EHP5045

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Arzuaga, Xabier ; Smith, Martyn T ; Gibbons, Catherine F ; Skakkebæk, Niels E ; Yost, Erin E ; Beverly, Brandiese E J ; Hotchkiss, Andrew K ; Hauser, Russ ; Pagani, Rodrigo L ; Schrader, Steven M ; Zeise, Lauren ; Prins, Gail S. / Proposed Key Characteristics of Male Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Evidence in Human Health Hazard Assessments. I: Environmental Health Perspectives. 2019 ; Bind 127, Nr. 6. s. 65001.

Bibtex

@article{bd6c1bfa94c34a71a13dbf382b5a5525,
title = "Proposed Key Characteristics of Male Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Evidence in Human Health Hazard Assessments",
abstract = "BACKGROUND: Assessing chemicals for their potential to cause male reproductive toxicity involves the evaluation of evidence obtained from experimental, epidemiological, and mechanistic studies. Although mechanistic evidence plays an important role in hazard identification and evidence integration, the process of identifying, screening and analyzing mechanistic studies and outcomes is a challenging exercise due to the diversity of research models and methods and the variety of known and proposed pathways for chemical-induced toxicity. Ten key characteristics of carcinogens provide a valuable tool for organizing and assessing chemical-specific data by potential mechanisms for cancer-causing agents. However, such an approach has not yet been developed for noncancer adverse outcomes.OBJECTIVES: The objective in this study was to identify a set of key characteristics that are frequently exhibited by exogenous agents that cause male reproductive toxicity and that could be applied for identifying, organizing, and summarizing mechanistic evidence related to this outcome.DISCUSSION: The identification of eight key characteristics of male reproductive toxicants was based on a survey of known male reproductive toxicants and established mechanisms and pathways of toxicity. The eight key characteristics can provide a basis for the systematic, transparent, and objective organization of mechanistic evidence relevant to chemical-induced effects on the male reproductive system. https://doi.org/10.1289/EHP5045.",
author = "Xabier Arzuaga and Smith, {Martyn T} and Gibbons, {Catherine F} and Skakkeb{\ae}k, {Niels E} and Yost, {Erin E} and Beverly, {Brandiese E J} and Hotchkiss, {Andrew K} and Russ Hauser and Pagani, {Rodrigo L} and Schrader, {Steven M} and Lauren Zeise and Prins, {Gail S}",
year = "2019",
month = "6",
doi = "10.1289/EHP5045",
language = "English",
volume = "127",
pages = "65001",
journal = "Environmental Health Perspectives",
issn = "0091-6765",
publisher = "U.S. Department of Health and Human Services National Institute of Environmental Health Sciences",
number = "6",

}

RIS

TY - JOUR

T1 - Proposed Key Characteristics of Male Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Evidence in Human Health Hazard Assessments

AU - Arzuaga, Xabier

AU - Smith, Martyn T

AU - Gibbons, Catherine F

AU - Skakkebæk, Niels E

AU - Yost, Erin E

AU - Beverly, Brandiese E J

AU - Hotchkiss, Andrew K

AU - Hauser, Russ

AU - Pagani, Rodrigo L

AU - Schrader, Steven M

AU - Zeise, Lauren

AU - Prins, Gail S

PY - 2019/6

Y1 - 2019/6

N2 - BACKGROUND: Assessing chemicals for their potential to cause male reproductive toxicity involves the evaluation of evidence obtained from experimental, epidemiological, and mechanistic studies. Although mechanistic evidence plays an important role in hazard identification and evidence integration, the process of identifying, screening and analyzing mechanistic studies and outcomes is a challenging exercise due to the diversity of research models and methods and the variety of known and proposed pathways for chemical-induced toxicity. Ten key characteristics of carcinogens provide a valuable tool for organizing and assessing chemical-specific data by potential mechanisms for cancer-causing agents. However, such an approach has not yet been developed for noncancer adverse outcomes.OBJECTIVES: The objective in this study was to identify a set of key characteristics that are frequently exhibited by exogenous agents that cause male reproductive toxicity and that could be applied for identifying, organizing, and summarizing mechanistic evidence related to this outcome.DISCUSSION: The identification of eight key characteristics of male reproductive toxicants was based on a survey of known male reproductive toxicants and established mechanisms and pathways of toxicity. The eight key characteristics can provide a basis for the systematic, transparent, and objective organization of mechanistic evidence relevant to chemical-induced effects on the male reproductive system. https://doi.org/10.1289/EHP5045.

AB - BACKGROUND: Assessing chemicals for their potential to cause male reproductive toxicity involves the evaluation of evidence obtained from experimental, epidemiological, and mechanistic studies. Although mechanistic evidence plays an important role in hazard identification and evidence integration, the process of identifying, screening and analyzing mechanistic studies and outcomes is a challenging exercise due to the diversity of research models and methods and the variety of known and proposed pathways for chemical-induced toxicity. Ten key characteristics of carcinogens provide a valuable tool for organizing and assessing chemical-specific data by potential mechanisms for cancer-causing agents. However, such an approach has not yet been developed for noncancer adverse outcomes.OBJECTIVES: The objective in this study was to identify a set of key characteristics that are frequently exhibited by exogenous agents that cause male reproductive toxicity and that could be applied for identifying, organizing, and summarizing mechanistic evidence related to this outcome.DISCUSSION: The identification of eight key characteristics of male reproductive toxicants was based on a survey of known male reproductive toxicants and established mechanisms and pathways of toxicity. The eight key characteristics can provide a basis for the systematic, transparent, and objective organization of mechanistic evidence relevant to chemical-induced effects on the male reproductive system. https://doi.org/10.1289/EHP5045.

U2 - 10.1289/EHP5045

DO - 10.1289/EHP5045

M3 - Journal article

VL - 127

SP - 65001

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

IS - 6

ER -

ID: 57374906