@article{91b2c3c1b76a4bffa34e17abfb99bcf8,
title = "Promotor polymorphisms in leukotriene C4 synthase and risk of ischemic cerebrovascular disease.",
abstract = "OBJECTIVE: Cysteinyl leukotrienes are involved in inflammation and possibly in early carotid atherosclerosis. We tested the hypothesis that the -444 A/C and -1072 G/A polymorphisms of the leukotriene C(4) synthase associate with risk of ischemic cerebrovascular disease. METHODS AND RESULTS: We genotyped 10 592 individuals from the Danish general population, the Copenhagen City Heart Study. During 24 years of follow-up, 557 individuals developed ischemic cerebrovascular disease. The allele frequency was 0.07 for -1072 A and 0.29 for -444 C. Cumulative incidence for ischemic cerebrovascular disease was higher for -1072 AA versus GG genotype (log-rank: P=0.002), and lower for -444 CC versus AA genotype (log-rank: P=0.008). Combined genotypes showed corresponding cumulative incidence differences (log-rank: P=0.003). Multifactorially adjusted hazard ratios for ischemic cerebrovascular disease were 2.8(1.4 to 5.7) for -1072 AA versus GG genotype, 0.6(0.4 to 0.9) for -444 CC versus AA genotype, 2.5(1.2 to 5.4) for combined AA-AA versus GG-AA genotype, and 0.6(0.4 to 0.9) for combined GG-CC versus GG-AA genotype. Genotype did not associate with risk of deep venous thrombosis or severe carotid atherosclerosis, or with levels of platelets and coagulation factors. CONCLUSIONS: Leukotriene C(4) synthase -1072 AA genotype predict increased risk, whereas -444 CC genotype predict decreased risk of ischemic cerebrovascular disease.",
keywords = "Adult, Aged, Aged, 80 and over, Carotid Artery Diseases, Case-Control Studies, Cerebrovascular Disorders, Cross-Sectional Studies, Cysteine, Female, Follow-Up Studies, Gene Frequency, Genetic Predisposition to Disease, Glutathione Transferase, Humans, Leukotrienes, Linkage Disequilibrium, Male, Middle Aged, Polymorphism, Genetic, Predictive Value of Tests, Prospective Studies, Risk Factors, Stroke, Venous Thrombosis",
author = "Freiberg, {Jacob J} and Anne Tybj{\ae}rg-Hansen and Henrik Sillesen and Jensen, {Gorm B} and Nordestgaard, {B{\o}rge G}",
year = "2008",
doi = "10.1161/ATVBAHA.107.158873",
language = "English",
volume = "28",
pages = "990--6",
journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",
issn = "1079-5642",
publisher = "Lippincott Williams and Wilkins",
number = "5",
}